Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon

• Published in: British journal of pharmacology Vol. 122; no. 2; pp. 265 - 268
• Main Authors: Mackness, Bharti, Mackness, Michael I., Arrol, Sharon, Turkie, Wajdi, Durrington, Paul N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.1997; Nature Publishing
• Subjects: Adult; Arteriosclerosis - genetics; Aryldialkylphosphatase; Biological and medical sciences; Esterases - blood; Esterases - genetics; Esterases - metabolism; Female; Genetic Predisposition to Disease; Gulf War Syndrome; Humans; Insecticides - metabolism; Insecticides - poisoning; Male; Medical sciences; Middle Aged; OP intoxication; Paraoxon - metabolism; Paraoxonase; Pesticides, fertilizers and other agrochemicals toxicology; Polymorphism, Genetic; PON1; Toxicology; Human; Insecticide; Enzyme; Toxicity; Metabolism toxicity relation; Enzyme inhibitor; Esterases; Risk analysis; Metabolism; In vitro; Cholinesterase; Carboxylic ester hydrolases; Blood plasma; Hydrolysis; Toxicogenetics; Interindividual comparison; Hydrolases; Genetics; Serum; Poisoning; Organophosphorus compounds; Anticholinesterase agent; Aminoacid sequence; Polymorphism

1 The hydrolysis of organophosphate pesticides (OP) and nerve gases by serum paraoxonase (PON1) is an important factor determining their toxicity to mammals including man. The PON1 gene contains 2 polymorphic sites at amino acid positions 55 (L→M) and 192 (G→A, classically defined as the A and B gen...