Neuroinflammation and Not Tauopathy Is a Predominant Pathological Signature of Nodding Syndrome

• Published in: Journal of neuropathology and experimental neurology Vol. 78; no. 11; pp. 1049 - 1058
• Main Authors: Hotterbeekx, An, Lammens, Martin, Idro, Richard, Akun, Pamela R, Lukande, Robert, Akena, Geoffrey, Nath, Avindra, Taylor, Joneé, Olwa, Francis, Kumar-Singh, Samir, Colebunders, Robert
• Format: Journal Article
• Language: English
• Published: Cary Oxford University Press 01.11.2019; by American Association of Neuropathologists, Inc
• Subjects: Diagnosis; Epilepsy; Hyperplasia; Inflammation; Onchocerciasis; Original; Patient outcomes; Uganda; Uganda; Onchocerciasis; Epilepsy; Nodding syndrome; Postmortem

Abstract Nodding syndrome (NS) is an epileptic disorder occurring in children in African onchocerciasis endemic regions. Here, we describe the pathological changes in 9 individuals from northern Uganda who died with NS (n = 5) or other forms of onchocerciasis-associated epilepsy (OAE) (n = 4). Postm...