Trypsin inhibitors demonstrate antioxidant activities, inhibit A549 cell proliferation, and increase activities of reactive oxygen species scavenging enzymes

• Published in: Indian journal of pharmacology Vol. 49; no. 2; pp. 155 - 160
• Main Authors: Shamsi, ToobaNaz, Parveen, Romana, Fatima, Sadaf
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.03.2017; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: A549 Cells; Acids; Antineoplastic Agents - pharmacology; Antioxidants; Antioxidants (Nutrients); Antioxidants - pharmacology; Apoptosis; Biotechnology; Cancer; Cell adhesion & migration; Cell cycle; Cell growth; Cell Proliferation - drug effects; Cell Survival - drug effects; Cytotoxicity; Enzymes; Garlic; Glutathione Peroxidase - metabolism; Glutathione Transferase - metabolism; HEK293 Cells; Humans; Metastasis; Oxidative stress; Phaseolus; Physiological aspects; Reactive oxygen species; Reactive Oxygen Species - metabolism; Seeds; Signal transduction; Superoxide Dismutase - metabolism; Trypsin inhibitors; Trypsin Inhibitors - pharmacology; Vigna; lung cancer; Antioxidant; protein; protein protease inhibitors

Protease inhibitors are one of the most promising and investigated subjects for their role in pharmacognostical and pharmacological studies. This study aimed to investigate antineoplastic and antioxidant activity of trypsin inhibitors (TIs) isolated from three plant sources and their inhibitory role...