JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction - Peng, Dewei; He, Xiaoli; Ren, Bowen; Wang, Qian; Peng, Lulu; Jiang, Yue; Huo, Shengqi; Men, Lintong; Shi, Wei; Luo, Pengcheng; Zhu, Mengyin; Zhang, Cuntai; et al. (Molecular medicine (Cambridge, Mass.), 2025)
Keywords: Animals; Cardiac dysfunction; Disease Models, Animal; Heart Diseases - etiology; Heart Diseases - metabolism; HMGCS2; Hyperuricemia; Hyperuricemia - complications; Hyperuricemia - metabolism; JAK2; Janus Kinase 2 - metabolism; Male; Mice; Mice, Inbred C57BL; Mitochondria - metabolism; Mitochondrial function; Myocytes, Cardiac - metabolism; Oxidative Stress; Signal Transduction; STAT3; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Uric Acid; Hyperuricemia; HMGCS2; JAK2; Mitochondrial function; Cardiac dysfunction; STAT3