Molecular and phenotypic distinctions of macrophages in tolerant and susceptible to hypoxia rats

• Published in: PeerJ (San Francisco, CA) Vol. 11; p. e16052
• Main Authors: Dzhalilova, Dzhuliia, Kosyreva, Anna, Lokhonina, Anastasiya, Tsvetkov, Ivan, Vishnyakova, Polina, Makarova, Olga, Fatkhudinov, Timur
• Format: Journal Article
• Language: English
• Published: San Diego, USA PeerJ. Ltd 10.10.2023; PeerJ Inc
• Subjects: Biochemistry; Cell Biology; DNA binding proteins; Gene expression; HIF-1; Hypoxia tolerance; Inflammation; Macrophage; Macrophages; Molecular Biology; Rats; RNA; Vascular endothelial growth factor; Germany; California; Russia
• ISSN: 2167-8359; 2167-8359
• DOI: 10.7717/peerj.16052

Individual hypoxia tolerance is a major influence on the course and outcome of infectious and inflammatory diseases. Macrophages, which play central roles in systemic inflammatory response and other immunity reactions, are subject to functional activation orchestrated by several transcription factor...