Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop

• Published in: Nature communications Vol. 9; no. 1; pp. 3934 - 12
• Main Authors: Janus, Benjamin M, van Dyk, Nydia, Zhao, Xuelian, Howell, Katie A, Soto, Cinque, Aman, M Javad, Li, Yuxing, Fuerst, Thomas R, Ofek, Gilad
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 26.09.2018; Nature Publishing Group UK; Nature Portfolio
• Subjects: Antibodies; Antibodies, Neutralizing - chemistry; Binding Sites, Antibody; Crystal structure; Drug development; Ebolavirus - immunology; Epitopes; Glycoproteins; Neutralization; Outbreaks; Vaccines; Viral diseases; Viral Envelope Proteins - immunology; Viruses

The severity of the 2014-2016 ebolavirus outbreak in West Africa expedited clinical development of therapeutics and vaccines though the countermeasures on hand were largely monospecific and lacked efficacy against other ebolavirus species that previously emerged. Recent studies indicate that ebolavi...