Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections

• Published in: International journal of antimicrobial agents Vol. 44; no. 5; pp. 409 - 415
• Main Authors: Luque, S., Grau, S., Alvarez-Lerma, F., Ferrández, O., Campillo, N., Horcajada, J.P., Basas, M., Lipman, J., Roberts, J.A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2014
• Subjects: Acetamides - administration & dosage; Acetamides - blood; Acetamides - cerebrospinal fluid; Acetamides - pharmacokinetics; Adult; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - cerebrospinal fluid; Anti-Bacterial Agents - pharmacokinetics; blood; Central nervous system; Central Nervous System Infections - drug therapy; Cerebrospinal fluid; Cerebrospinal Fluid - chemistry; Critical Illness; Critically ill patients; drainage; drugs; Female; Humans; Infection; Infectious Disease; linear models; Linezolid; Male; microorganisms; Middle Aged; minimum inhibitory concentration; monitoring; multiple drug resistance; Neurosurgery; Oxazolidinones - administration & dosage; Oxazolidinones - blood; Oxazolidinones - cerebrospinal fluid; Oxazolidinones - pharmacokinetics; patients; Pharmacokinetics; Plasma - chemistry; Prospective Studies; therapeutics; Linezolid; Infection; Cerebrospinal fluid; Pharmacokinetics; Central nervous system; Critically ill patients

•In these patients, linezolid demonstrated good but variable penetration into the CNS.•A 3-compartment model was used; the mean value for linezolid clearance was 16.6L/h and volume of distribution 101.3L.•To ensure all patients achieve adequate CNS concentrations the use of higher than standard dose...