First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes - Yurtsever, Zeynep; Patel, Dhara A.; Kober, Daniel L.; Su, Alvin; Miller, Chantel A.; Romero, Arthur G.; Holtzman, Michael J.; Brett, Tom J. (Biochimica et biophysica acta, 2016)
Keywords: BASIC BIOLOGICAL SCIENCES; Binding Sites; Chronic inflammatory lung disease; crystal structure; Differential scanning fluorimetry; half life; Humans; hydrogen bonding; Inhibitor half-lives; inhibitory concentration 50; interferometry; Kinase inhibitor; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 13 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 13 - chemistry; Mitogen-Activated Protein Kinase 13 - metabolism; p38 kinase; pharmacokinetics; Protein Binding; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - pharmacology; Quantitative Structure-Activity Relationship; Structure-based drug design; p38 kinase; Structure-based drug design; Differential scanning fluorimetry; Chronic inflammatory lung disease; Kinase inhibitor; Inhibitor half-lives