Effect of Esophageal Emptying and Saliva on Clearance of Acid from the Esophagus

• Published in: The New England journal of medicine Vol. 310; no. 5; pp. 284 - 288
• Main Authors: Helm, James F, Dodds, Wylie J, Pelc, Lorie R, Palmer, David W, Hogan, Walter J, Teeter, Bruce C
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 02.02.1984
• Subjects: Accuracy; Acids - metabolism; Adult; Biological and medical sciences; Deglutition; Electrodes; Esophagus; Esophagus - diagnostic imaging; Esophagus - metabolism; Esophagus - physiology; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroesophageal reflux; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Male; Manometry; Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus; Peristalsis; pH effects; Radionuclide Imaging; Saliva; Saliva - physiology; Sulfur; Technetium; Vertebrates: digestive system; Human; Acids; Digestive system; Muscle contraction; Saliva; Esophagus

We studied clearance of acid from the esophagus and esophageal emptying in normal subjects. A 15-ml bolus of 0.1 N hydrochloric acid (pH 1.2) Radio-labeled with [ 99m Tc]sulfur colloid was injected into the esophagus, and the subject swallowed every 30 seconds. Concurrent manometry and radionuclide...