Amphiphilic polyesters bearing pendant sugar moieties: Synthesis, characterization, and cellular uptake

• Published in: Carbohydrate Polymers Vol. 99; pp. 710 - 719
• Main Authors: Peng, Kang-Yu, Hua, Mu-Yi, Lee, Ren-Shen
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 2014; Elsevier BV; Elsevier
• Subjects: Antibiotics, Antineoplastic; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacology; Applied sciences; Biological and medical sciences; Block-graft polymer; Cell Survival; Cell Survival - drug effects; Cellular uptake; cytotoxicity; Doxorubicin; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug Carriers; Drug Carriers - chemical synthesis; Drug Compounding; Drug delivery; Endocytosis; Exact sciences and technology; General pharmacology; Glycopolymer; glycosylation; HeLa Cells; Humans; Medical sciences; Micelles; Organic polymers; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polyesters; Polyesters - chemistry; polymerization; Polymers with particular properties; Polysaccharides; Polysaccharides - chemistry; Preparation, kinetics, thermodynamics, mechanism and catalysts; sugars; Glycopolymer; Cellular uptake; Drug delivery; Block-graft polymer; Biological properties; Antineoplastic agent; 1,3-Dipolar cycloaddition; Lectin; Triazole derivative copolymer; Indometacin; Chlorine containing copolymer; Cytotoxicity; Drug carrier; Doxorubicin; Lateral group; Endocytosis; Binding capacity; Caprolactone copolymer; Micellar critical concentration; Glycoside; Release; Amphiphilic polymer; Lactone copolymer; Control release polymer; Experimental study; Hela cell line; Non steroidal antiinflammatory agent; Azides; Chemical modification; Internalization; Preparation; Diblock copolymer; Kinetics; Aqueous solution; Nucleophilic substitution; Ring opening copolymerization

•Amphiphilic block-graft (PαN3CL-g-Sugar)-b-PCL polymers were synthesized.•Glycosylated polymers can be used in biorecognition applications, and has low cytotoxicity.•Micelles facilitated an improved uptake of DOX and entreated the nuclei by endocytosis. Ring-opening polymerization (ROP) and “click”...