Benzophenone guttiferone A from Garcinia achachairu Rusby (Clusiaceae) presents genotoxic effects in different cells of mice

• Published in: PloS one Vol. 8; no. 11; p. e76485
• Main Authors: Terrazas, Peterson Menezes, de Souza Marques, Eduardo, Mariano, Luisa Nathália Bolda, Cechinel-Filho, Valdir, Niero, Rivaldo, Andrade, Sergio Faloni, Maistro, Edson Luis
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.11.2013; Public Library of Science (PLoS)
• Subjects: Animals; Aqueous solutions; Benzophenone; Benzophenones - chemistry; Benzophenones - toxicity; Bioassay; Bioassays; Biocompatibility; Biological properties; Bone marrow; Bone Marrow - drug effects; Brain; Brain - drug effects; Clusiaceae; Comet assay; Cytotoxicity; Damage detection; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - drug effects; Erythrocytes; Folk medicine; Garcinia; Garcinia - chemistry; Genotoxicity; In vivo methods and tests; Leukocytes; Leukocytes - drug effects; Liver; Liver - drug effects; Male; Mice; Mutagenesis; NMR; Nuclear magnetic resonance; Phytochemicals; Plant Extracts - chemistry; Plant Extracts - toxicity; Rheedia; Seeds; Testis - drug effects; Toxicity testing; Brazil

Benzophenones from natural sources and those of synthetic analogues present several reports of potent biological properties, and Guttiferone A represents a promising medicinal natural compound with analgesic and gastroprotective profiles. Considering that there are no reports that assess the genetic...