Neuropeptide Y and its receptors in ventricular endocardial endothelial cells

Endocardial endothelial cells (EECs) constitute an important component of the heart. These cells form a monolayer that covers the cavities of the right (EECRs) and left (EECLs) ventricles. They play an important role in cardiac excitation–contraction coupling via their secretion of cardioactive fact...

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Published in	Canadian journal of physiology and pharmacology Vol. 95; no. 10; pp. 1224 - 1229
Main Authors	Jacques, Danielle, D’Orléans-Juste, Pedro, Magder, Sheldon, Bkaily, Ghassan
Format	Journal Article
Language	English
Published	Canada NRC Research Press 01.10.2017 Canadian Science Publishing NRC Research Press
Subjects	Animals Cardiovascular disease Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - physiopathology Endocardium - metabolism Endocardium - pathology Endocardium - physiopathology Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Heart Heart diseases Heart Ventricles - metabolism Heart Ventricles - pathology Heart Ventricles - physiopathology Humans Neuropeptide Y Neuropeptide Y - metabolism Neuropeptides Pharmacology Physiological aspects Physiology Receptors, Neuropeptide Y - metabolism Signal Transduction Ventricle Canada endocardial endothelial cells ET-1 calcium NPY récepteurs du NPY NPY receptors cellules endothéliales endocardiques
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Abstract	Endocardial endothelial cells (EECs) constitute an important component of the heart. These cells form a monolayer that covers the cavities of the right (EECRs) and left (EECLs) ventricles. They play an important role in cardiac excitation–contraction coupling via their secretion of cardioactive factors such as neuropeptide Y (NPY). They also contribute to cardiac pathology such as arrhythmia, hypertrophy, and heart failure. Differences between EECRs and EECLs contribute to tuning of circulating factors at the entry and exit of the ventricles. NPY, via activation of its receptors, modulates the excitation–secretion coupling of EECs, thus, indirectly modulating cardiac function and remodeling.
AbstractList	Endocardial endothelial cells (EECs) constitute an important component of the heart. These cells form a monolayer that covers the cavities of the right (EECRs) and left (EECLs) ventricles. They play an important role in cardiac excitation-contraction coupling via their secretion of cardioactive factors such as neuropeptide Y (NPY). They also contribute to cardiac pathology such as arrhythmia, hypertrophy, and heart failure. Differences between EECRs and EECLs contribute to tuning of circulating factors at the entry and exit of the ventricles. NPY, via activation of its receptors, modulates the excitation-secretion coupling of EECs, thus, indirectly modulating cardiac function and remodeling.Endocardial endothelial cells (EECs) constitute an important component of the heart. These cells form a monolayer that covers the cavities of the right (EECRs) and left (EECLs) ventricles. They play an important role in cardiac excitation-contraction coupling via their secretion of cardioactive factors such as neuropeptide Y (NPY). They also contribute to cardiac pathology such as arrhythmia, hypertrophy, and heart failure. Differences between EECRs and EECLs contribute to tuning of circulating factors at the entry and exit of the ventricles. NPY, via activation of its receptors, modulates the excitation-secretion coupling of EECs, thus, indirectly modulating cardiac function and remodeling. Endocardial endothelial cells (EECs) constitute an important component of the heart. These cells form a monolayer that covers the cavities of the right (EECRs) and left (EECLs) ventricles. They play an important role in cardiac excitation-contraction coupling via their secretion of cardioactive factors such as neuropeptide Y (NPY). They also contribute to cardiac pathology such as arrhythmia, hypertrophy, and heart failure. Differences between EECRs and EECLs contribute to tuning of circulating factors at the entry and exit of the ventricles. NPY, via activation of its receptors, modulates the excitation-secretion coupling of EECs, thus, indirectly modulating cardiac function and remodeling. Endocardial endothelial cells (EECs) constitute an important component of the heart. These cells form a monolayer that covers the cavities of the right (EECRs) and left (EECLs) ventricles. They play an important role in cardiac excitation-contraction coupling via their secretion of cardioactive factors such as neuropeptide Y (NPY). They also contribute to cardiac pathology such as arrhythmia, hypertrophy, and heart failure. Differences between EECRs and EECLs contribute to tuning of circulating factors at the entry and exit of the ventricles. NPY, via activation of its receptors, modulates the excitation-secretion coupling of EECs, thus, indirectly modulating cardiac function and remodeling. Key words: NPY, NPY receptors, endocardial endothelial cells, ET-1, calcium. Les cellules endotheliales endocardiques (CEE) constituent une composante importante du creur. Ces cellules forment une monocouche qui tapisse les cavites des ventricules droit (CEED) et gauche (CEEG). Elles jouent un role important dans le couplage excitation-contraction du creur par l'intermediaire de la secretion de facteurs cardioactifs comme le neuropeptide Y (NPY). Elles contribuent aussi a des pathologies cardiaques comme les arythmies ainsi que l'hypertrophie et l'insuffisance cardiaques. Les differences entre les CEED et les CEEG contribuent a l'ajustement de facteurs circulants a l'entree et a la sortie des ventricules. Le NPY, par l'intermediaire de l'activation de ses recepteurs, assure la modulation du couplage excitationsecretion des CEE, et par consequent la modulation de la fonction cardiaque et du remodelage du creur. [Traduit par la Redaction] Mots-cles: NPY, recepteurs du NPY, cellules endotheliales endocardiques, ET-1, calcium.
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Author	Jacques, Danielle Bkaily, Ghassan D’Orléans-Juste, Pedro Magder, Sheldon
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SubjectTerms	Animals Cardiovascular disease Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - physiopathology Endocardium - metabolism Endocardium - pathology Endocardium - physiopathology Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Heart Heart diseases Heart Ventricles - metabolism Heart Ventricles - pathology Heart Ventricles - physiopathology Humans Neuropeptide Y Neuropeptide Y - metabolism Neuropeptides Pharmacology Physiological aspects Physiology Receptors, Neuropeptide Y - metabolism Signal Transduction Ventricle
Title	Neuropeptide Y and its receptors in ventricular endocardial endothelial cells
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