REM sleep homeostasis in the absence of REM sleep: Effects of antidepressants

• Published in: Neuropharmacology Vol. 108; pp. 415 - 425
• Main Authors: McCarthy, Andrew, Wafford, Keith, Shanks, Elaine, Ligocki, Marcin, Edgar, Dale M., Dijk, Derk-Jan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2016
• Subjects: Animals; Antidepressive Agents - pharmacology; Antidepressive Agents, Tricyclic - pharmacology; Homeostasis - drug effects; Homeostasis - physiology; Male; Paradoxical sleep; Rats; Rats, Wistar; Recovery; Selective serotonin reuptake inhibitors; Serotonin Uptake Inhibitors - pharmacology; Sleep deprivation; Sleep, REM - drug effects; Sleep, REM - physiology; Tricyclic antidepressants; Selective serotonin reuptake inhibitors; Paradoxical sleep; Recovery; Tricyclic antidepressants; Sleep deprivation

Most antidepressants suppress rapid eye movement (REM) sleep, which is thought to be important to brain function, yet the resulting REM sleep restriction is well tolerated. This study investigated the impact of antidepressants with different mechanisms of action, such as selective serotonin reuptake...