Aspirin or Nonsteroidal Anti-inflammatory Drug-Exacerbated Chronic Rhinosinusitis

• Published in: The journal of allergy and clinical immunology in practice (Cambridge, MA) Vol. 4; no. 4; p. 590
• Main Authors: Ledford, Dennis K, Lockey, Richard F
• Format: Journal Article
• Language: English
• Published: United States 01.07.2016
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Aspirin - adverse effects; Chronic Disease; Comorbidity; Humans; Rhinitis - epidemiology; Rhinitis - etiology; Rhinitis - physiopathology; Rhinitis - therapy; Sinusitis - epidemiology; Sinusitis - etiology; Sinusitis - physiopathology; Sinusitis - therapy; Leukotriene; Nasal polyps; Rhinosinusitis; Aspirin-exacerbated respiratory disease; Nonsteroidal anti-inflammatory drug

Aspirin (ASA)-exacerbated respiratory disease (AERD) is characterized by upper airway congestion due to eosinophilic inflammation of the nasal and sinus membranes and nasal polyposis, associated with increased leukotriene production that is further accentuated by ASA or other nonsteroidal anti-infla...