Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly

• Published in: NeuroImage (Orlando, Fla.) Vol. 25; no. 3; pp. 783 - 792
• Main Authors: Csernansky, J.G., Wang, L., Swank, J., Miller, J.P., Gado, M., McKeel, D., Miller, M.I., Morris, J.C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2005; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer's disease; Brain; Brain research; Clinical Dementia Rating scale; DAT; Dementia; Dentate Gyrus - pathology; Dominance, Cerebral - physiology; Early Diagnosis; Female; Follow-Up Studies; Hippocampus - pathology; Humans; Image Enhancement; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mathematical Computing; Middle Aged; Neuropsychological Tests; Organ Size; Predictive Value of Tests; Proportional Hazards Models; Reference Values; Risk Assessment; Studies; Alzheimer's disease; Clinical Dementia Rating scale; DAT

Structural deformity of the hippocampus is characteristic of individuals with very mild and mild forms of dementia of the Alzheimer type (DAT). The purpose of this study was to determine whether a similar deformity of the hippocampus can predict the onset of dementia in nondemented elders. Using hig...