Association of MicroRNA-196a-2 Gene Polymorphism with Gastric Cancer Risk in a Chinese Population

• Published in: Digestive diseases and sciences Vol. 55; no. 8; pp. 2288 - 2293
• Main Authors: Peng, Sheng, Kuang, Zhongshen, Sheng, Chenyi, Zhang, Yan, Xu, Hang, Cheng, Qinghong
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.08.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Aged; Asian Continental Ancestry Group; Biochemistry; Biological and medical sciences; Cancer; Case-Control Studies; China - epidemiology; Chromosomes; Development and progression; Disease susceptibility; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Genetic aspects; Genetic Predisposition to Disease; Health aspects; Hepatology; Heterozygote; Homozygote; Humans; Male; Medical sciences; Medicine; Medicine & Public Health; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Odds Ratio; Oncology; Oncology, Experimental; Original Article; Polymorphism, Genetic; Risk factors; Single nucleotide polymorphisms; Stomach cancer; Stomach Neoplasms - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transplant Surgery; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; China; microRNA-196a-2; Gastric cancer; Carcinogenesis; Polymorphism; Risk factor; Gastroenterology; Digestive diseases; Metabolic diseases; Malignant tumor; Stomach cancer; Cancer; Gastric disease
• ISSN: 0163-2116; 1573-2568; 1573-2568
• DOI: 10.1007/s10620-009-1007-x

Background It has been proposed that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) could affect the expression of the miRNA and contribute to the susceptibility of human tumors. However, the role of genetic variant (T/C) in miR-196a-2 in gastric cancer susceptibility is still unknown....