Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease

• Published in: Brain (London, England : 1878) Vol. 131; no. 11; pp. 2851 - 2859
• Main Authors: Leoni, Valerio, Mariotti, Caterina, Tabrizi, Sarah J., Valenza, Marta, Wild, Edward J., Henley, Susie M. D., Hobbs, Nicola Z., Mandelli, Maria Luisa, Grisoli, Marina, Björkhem, Ingemar, Cattaneo, Elena, Di Donato, Stefano
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2008; Oxford Publishing Limited (England)
• Subjects: 24S-hydroxycholesterol; Adult; Biological and medical sciences; biomarker; Biomarkers - blood; Brain Mapping - methods; Caudate Nucleus - pathology; caudate volume; Cholesterol - blood; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Progression; Female; gas chromatography-mass spectrometry; Gas Chromatography-Mass Spectrometry - methods; Humans; Huntington Disease - blood; Huntington Disease - pathology; Hydroxycholesterols - blood; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; MRI; Neurology; oxysterol; Prognosis; Young Adult; oxysterol; gas chromatography-mass spectrometry; 24S-hydroxycholesterol; biomarker; caudate volume; MRI; Nervous system diseases; Huntington disease; Nuclear magnetic resonance imaging; Genetic disease; Cerebral disorder; Gas chromatography; Central nervous system disease; Degenerative disease; Mass spectrometry; Extrapyramidal syndrome

Huntington's disease (HD) is a hereditary neurodegenerative disorder for which biological indicators of disease progression, or disease stage, would be especially important for therapeutic trials. 24S-hydroxycholesterol (24OHC) is a brain-generated cholesterol metabolite which has been associat...