A Novel Gli3 Enhancer Controls the Gli3 Spatiotemporal Expression Pattern through a TALE Homeodomain Protein Binding Site

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Published inMolecular and Cellular Biology Vol. 31; no. 7; pp. 1432 - 1443
Main Authors Coy, Sarah, Caamaño, Jorge H., Carvajal, Jaime, Cleary, Michael L., Borycki, Anne-Gaëlle
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.04.2011
Taylor & Francis
Subjects
Animals
Base Sequence
Binding Sites
Chickens
Embryo, Mammalian - metabolism
Enhancer Elements, Genetic - genetics
Gene Expression Regulation, Developmental
Genetic Loci - genetics
Genome - genetics
Homeodomain Proteins - metabolism
Humans
Introns - genetics
Kruppel-Like Transcription Factors - genetics
Kruppel-Like Transcription Factors - metabolism
Mice
Models, Biological
Molecular Sequence Data
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Neural Tube - metabolism
PC12 Cells
Pre-B-Cell Leukemia Transcription Factor 1
Protein Binding
Protein Multimerization
Rats
Time Factors
Transcription Factors - deficiency
Transcription, Genetic
Zinc Finger Protein Gli3
Online AccessGet full text

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Abstract Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
AbstractList Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
The zinc finger transcription factor Gli3 is an essential mediator of hedgehog signaling. Gli3 has a dynamic expression pattern during embryonic development. In the neural tube, Gli3 transcripts are patterned along the anteroposterior and dorsoventral axes such that the initial broad expression in the posterior neural tube becomes dorsally restricted as neurogenesis takes place. Little is known about the molecular mechanisms that regulate this dynamic expression. Here, we report on a phylogenetic analysis of the Gli3 locus that uncovered a novel regulatory element, HCNE1. HCNE1 contains a compound Pbx/Meis binding site that binds Pbx and Meis/Prep proteins in vitro and in vivo . We show that HCNE1 recapitulates Gli3 expression in the developing neural tube and that mutations in the Pbx/Meis binding site affect the spatiotemporal control of HCNE1 transcriptional activity. Ectopic expression or loss of function of Pbx and Meis/Prep proteins in the chick and mouse embryo results in aberrant expression of endogenous Gli3 transcripts. We propose a novel role for TALE proteins in establishing the correct spatiotemporal expression pattern of Gli3 in the vertebrate spinal cord, thus implicating TALE transcription factors in early embryonic patterning events controlled by Sonic hedgehog signaling.
The zinc finger transcription factor Gli3 is an essential mediator of hedgehog signaling. Gli3 has a dynamic expression pattern during embryonic development. In the neural tube, Gli3 transcripts are patterned along the anteroposterior and dorsoventral axes such that the initial broad expression in the posterior neural tube becomes dorsally restricted as neurogenesis takes place. Little is known about the molecular mechanisms that regulate this dynamic expression. Here, we report on a phylogenetic analysis of the Gli3 locus that uncovered a novel regulatory element, HCNE1. HCNE1 contains a compound Pbx/Meis binding site that binds Pbx and Meis/Prep proteins in vitro and in vivo. We show that HCNE1 recapitulates Gli3 expression in the developing neural tube and that mutations in the Pbx/Meis binding site affect the spatiotemporal control of HCNE1 transcriptional activity. Ectopic expression or loss of function of Pbx and Meis/Prep proteins in the chick and mouse embryo results in aberrant expression of endogenous Gli3 transcripts. We propose a novel role for TALE proteins in establishing the correct spatiotemporal expression pattern of Gli3 in the vertebrate spinal cord, thus implicating TALE transcription factors in early embryonic patterning events controlled by Sonic hedgehog signaling.
Author Michael L. Cleary
Jorge H. Caamaño
Jaime Carvajal
Anne-Gaëlle Borycki
Sarah Coy
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Snippet Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
The zinc finger transcription factor Gli3 is an essential mediator of hedgehog signaling. Gli3 has a dynamic expression pattern during embryonic development....
The zinc finger transcription factor Gli3 is an essential mediator of hedgehog signaling. Gli3 has a dynamic expression pattern during embryonic development....
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StartPage 1432
SubjectTerms Animals
Base Sequence
Binding Sites
Chickens
Embryo, Mammalian - metabolism
Enhancer Elements, Genetic - genetics
Gene Expression Regulation, Developmental
Genetic Loci - genetics
Genome - genetics
Homeodomain Proteins - metabolism
Humans
Introns - genetics
Kruppel-Like Transcription Factors - genetics
Kruppel-Like Transcription Factors - metabolism
Mice
Models, Biological
Molecular Sequence Data
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Neural Tube - metabolism
PC12 Cells
Pre-B-Cell Leukemia Transcription Factor 1
Protein Binding
Protein Multimerization
Rats
Time Factors
Transcription Factors - deficiency
Transcription, Genetic
Zinc Finger Protein Gli3
Title A Novel Gli3 Enhancer Controls the Gli3 Spatiotemporal Expression Pattern through a TALE Homeodomain Protein Binding Site
URI http://mcb.asm.org/content/31/7/1432.abstract
https://www.tandfonline.com/doi/abs/10.1128/MCB.00451-10
https://www.ncbi.nlm.nih.gov/pubmed/21262763
https://search.proquest.com/docview/857816335
https://pubmed.ncbi.nlm.nih.gov/PMC3135294
Volume 31
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