Voltammetric Sensor for Doxorubicin Determination Based on Self-Assembled DNA-Polyphenothiazine Composite

A novel voltammetric sensor based on a self-assembled composite formed by native DNA and electropolymerized N-phenyl-3-(phenylimino)-3H-phenothiazin-7-amine has been developed and applied for sensitive determination of doxorubicin, an anthracycline drug applied for cancer therapy. For this purpose,...

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Published inNanomaterials (Basel, Switzerland) Vol. 13; no. 16; p. 2369
Main Authors Malanina, Anastasiya, Kuzin, Yurii, Khadieva, Alena, Shibaeva, Kseniya, Padnya, Pavel, Stoikov, Ivan, Evtugyn, Gennady
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
MDPI
Subjects
Analysis
Anthracycline
Biosensors
Cancer therapies
Charge distribution
Composite materials
Deoxyribonucleic acid
DNA
DNA intercalation
DNA sensor
Doxorubicin
Drug screening
Electrochemical impedance spectroscopy
Electrochemistry
Electrodes
electropolymerization
Entrapment
Glassy carbon
Identification and classification
Impedance spectroscopy
Mathematical functions
Medical research
Methods
Nanoparticles
Optics
Phenothiazine
phenothiazine electropolymerization
Point of care testing
Polymerization
Polymers
Potassium
Properties
Scanning electron microscopy
Scanning microscopy
self-assembling
Self-assembly
Sensors
Software
Spectroscopy
Sulfuric acid
Surface layers
Voltammetry
Germany
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Abstract A novel voltammetric sensor based on a self-assembled composite formed by native DNA and electropolymerized N-phenyl-3-(phenylimino)-3H-phenothiazin-7-amine has been developed and applied for sensitive determination of doxorubicin, an anthracycline drug applied for cancer therapy. For this purpose, a monomeric phenothiazine derivative has been deposited on the glassy carbon electrode from the 0.4 M H2SO4-acetone mixture (1:1 v/v) by multiple potential cycling. The DNA aliquot was either on the electrode modified with electropolymerized film or added to the reaction medium prior to electropolymerization. The DNA entrapment and its influence on the redox behavior of the underlying layer were studied by scanning electron microscopy and electrochemical impedance spectroscopy. The DNA–doxorubicin interactions affected the charge distribution in the surface layer and, hence, altered the redox equilibrium of the polyphenothiazine coating. The voltametric signal was successfully applied for the determination of doxorubicin in the concentration range from 10 pM to 0.2 mM (limit of detection 5 pM). The DNA sensor was tested on spiked artificial plasma samples and two commercial medications (recovery of 90–95%). After further testing on real clinical samples, the electrochemical DNA sensor developed can find application in monitoring drug release and screening new antitumor drugs able to intercalate DNA.
AbstractList A novel voltammetric sensor based on a self-assembled composite formed by native DNA and electropolymerized N-phenyl-3-(phenylimino)-3H-phenothiazin-7-amine has been developed and applied for sensitive determination of doxorubicin, an anthracycline drug applied for cancer therapy. For this purpose, a monomeric phenothiazine derivative has been deposited on the glassy carbon electrode from the 0.4 M H 2 SO 4 -acetone mixture (1:1 v / v ) by multiple potential cycling. The DNA aliquot was either on the electrode modified with electropolymerized film or added to the reaction medium prior to electropolymerization. The DNA entrapment and its influence on the redox behavior of the underlying layer were studied by scanning electron microscopy and electrochemical impedance spectroscopy. The DNA–doxorubicin interactions affected the charge distribution in the surface layer and, hence, altered the redox equilibrium of the polyphenothiazine coating. The voltametric signal was successfully applied for the determination of doxorubicin in the concentration range from 10 pM to 0.2 mM (limit of detection 5 pM). The DNA sensor was tested on spiked artificial plasma samples and two commercial medications (recovery of 90–95%). After further testing on real clinical samples, the electrochemical DNA sensor developed can find application in monitoring drug release and screening new antitumor drugs able to intercalate DNA.
A novel voltammetric sensor based on a self-assembled composite formed by native DNA and electropolymerized N-phenyl-3-(phenylimino)-3H-phenothiazin-7-amine has been developed and applied for sensitive determination of doxorubicin, an anthracycline drug applied for cancer therapy. For this purpose, a monomeric phenothiazine derivative has been deposited on the glassy carbon electrode from the 0.4 M H2SO4-acetone mixture (1:1 v/v) by multiple potential cycling. The DNA aliquot was either on the electrode modified with electropolymerized film or added to the reaction medium prior to electropolymerization. The DNA entrapment and its influence on the redox behavior of the underlying layer were studied by scanning electron microscopy and electrochemical impedance spectroscopy. The DNA–doxorubicin interactions affected the charge distribution in the surface layer and, hence, altered the redox equilibrium of the polyphenothiazine coating. The voltametric signal was successfully applied for the determination of doxorubicin in the concentration range from 10 pM to 0.2 mM (limit of detection 5 pM). The DNA sensor was tested on spiked artificial plasma samples and two commercial medications (recovery of 90–95%). After further testing on real clinical samples, the electrochemical DNA sensor developed can find application in monitoring drug release and screening new antitumor drugs able to intercalate DNA.
A novel voltammetric sensor based on a self-assembled composite formed by native DNA and electropolymerized N-phenyl-3-(phenylimino)-3H-phenothiazin-7-amine has been developed and applied for sensitive determination of doxorubicin, an anthracycline drug applied for cancer therapy. For this purpose, a monomeric phenothiazine derivative has been deposited on the glassy carbon electrode from the 0.4 M H[sub.2] SO[sub.4] -acetone mixture (1:1 v/v) by multiple potential cycling. The DNA aliquot was either on the electrode modified with electropolymerized film or added to the reaction medium prior to electropolymerization. The DNA entrapment and its influence on the redox behavior of the underlying layer were studied by scanning electron microscopy and electrochemical impedance spectroscopy. The DNA–doxorubicin interactions affected the charge distribution in the surface layer and, hence, altered the redox equilibrium of the polyphenothiazine coating. The voltametric signal was successfully applied for the determination of doxorubicin in the concentration range from 10 pM to 0.2 mM (limit of detection 5 pM). The DNA sensor was tested on spiked artificial plasma samples and two commercial medications (recovery of 90–95%). After further testing on real clinical samples, the electrochemical DNA sensor developed can find application in monitoring drug release and screening new antitumor drugs able to intercalate DNA.
Audience Academic
Author Kuzin, Yurii
Khadieva, Alena
Padnya, Pavel
Malanina, Anastasiya
Evtugyn, Gennady
Shibaeva, Kseniya
Stoikov, Ivan
AuthorAffiliation 1 A.M. Butlerov Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russia
2 Analytical Chemistry Department, Chemical Technology Institute, Ural Federal University, 19 Mira Street, Ekaterinburg 620002, Russia
AuthorAffiliation_xml – name: 1 A.M. Butlerov Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russia
– name: 2 Analytical Chemistry Department, Chemical Technology Institute, Ural Federal University, 19 Mira Street, Ekaterinburg 620002, Russia
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CitedBy_id crossref_primary_10_3390_nano13233062
crossref_primary_10_3390_bios14030120
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Snippet A novel voltammetric sensor based on a self-assembled composite formed by native DNA and electropolymerized N-phenyl-3-(phenylimino)-3H-phenothiazin-7-amine...
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StartPage 2369
SubjectTerms Analysis
Anthracycline
Biosensors
Cancer therapies
Charge distribution
Composite materials
Deoxyribonucleic acid
DNA
DNA intercalation
DNA sensor
Doxorubicin
Drug screening
Electrochemical impedance spectroscopy
Electrochemistry
Electrodes
electropolymerization
Entrapment
Glassy carbon
Identification and classification
Impedance spectroscopy
Mathematical functions
Medical research
Methods
Nanoparticles
Optics
Phenothiazine
phenothiazine electropolymerization
Point of care testing
Polymerization
Polymers
Potassium
Properties
Scanning electron microscopy
Scanning microscopy
self-assembling
Self-assembly
Sensors
Software
Spectroscopy
Sulfuric acid
Surface layers
Voltammetry
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Title Voltammetric Sensor for Doxorubicin Determination Based on Self-Assembled DNA-Polyphenothiazine Composite
URI https://www.proquest.com/docview/2857413502
https://search.proquest.com/docview/2857848491
https://pubmed.ncbi.nlm.nih.gov/PMC10459114
https://doaj.org/article/cd01ef0589264f69b69ab1288389a334
Volume 13
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