Selective protein enrichment in calcium oxalate stone matrix: a window to pathogenesis?

• Published in: Urolithiasis Vol. 47; no. 6; pp. 521 - 532
• Main Authors: Wesson, Jeffrey A., Kolbach-Mandel, Ann M., Hoffmann, Brian R., Davis, Carley, Mandel, Neil S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2019; Springer Nature B.V
• Subjects: Calcium Oxalate - analysis; Calcium Oxalate - metabolism; Crystallization; Humans; Kidney Calculi - chemistry; Kidney Calculi - etiology; Kidney stones; Medical Biochemistry; Medicine; Medicine & Public Health; Nephrology; Original Paper; Pathogenesis; Proteins; Proteome - metabolism; Urinary Calculi - etiology; Urine; Urology; Kidney calculi; Urine proteome; Calcium oxalate; Nephrolithiasis

Urine proteins are thought to control calcium oxalate stone formation, but over 1000 proteins have been reported in stone matrix obscuring their relative importance. Proteins critical to stone formation should be present at increased relative abundance in stone matrix compared to urine, so quantitat...