Angiotensin 1-7 and its analogue decrease blood pressure but aggravate renal damage in preeclamptic mice

• Published in: Experimental Animals Vol. 71; no. 4; pp. 519 - 528
• Main Authors: Liu, Yuan, Zhai, Ruonan, Tong, Jiahao, Yu, Ying, Yang, Lin, Gu, Yong, Niu, Jianying
• Format: Journal Article
• Language: English
• Published: Tokyo Japanese Association for Laboratory Animal Science 01.01.2022; Japan Science and Technology Agency
• Subjects: agonistic autoantibodies to the angiotensin II type I receptor; Albumins; Angiotensin; angiotensin 1-7; Angiotensin II; animal model; Antibodies; Autoantibodies; Blood pressure; Creatinine; Damage; Electron microscopy; Fetuses; Guinea pigs; Hypertension; Intravenous administration; Kidneys; Pathogenesis; Pre-eclampsia; Preeclampsia; Pregnancy; Pregnancy complications; Pressure effects; Proteinuria; renal damage; Urea

Preeclampsia (PE) is a multisystem disease that affects the health of both the pregnant women and the fetus during pregnancy. Agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) play a significant role in the pathogenesis of PE. This study aimed to determine the effects of Angiot...