Biodistribution of gadolinium-based contrast agents, including gadolinium deposition

• Published in: Journal of magnetic resonance imaging Vol. 30; no. 6; pp. 1259 - 1267
• Main Authors: Aime, Silvio, Caravan, Peter
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2009
• Subjects: Animals; biodistribution; Contrast Media - chemistry; Contrast Media - pharmacokinetics; gadolinium; Gadolinium - adverse effects; Gadolinium - chemistry; Gadolinium - pharmacokinetics; Humans; Metabolic Clearance Rate; MRI; nephrogenic systemic fibrosis; Organ Specificity; retention; Tissue Distribution

The biodistribution of approved gadolinium (Gd)‐based contrast agents (GBCAs) is reviewed. After intravenous injection GBCAs distribute in the blood and the extracellular space and transiently through the excretory organs. Preclinical animal studies and the available clinical literature indicate tha...