Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase

• Published in: Journal of pharmacy and pharmacology Vol. 64; no. 2; pp. 237 - 243
• Main Authors: Stell, J. Godfrey P., Wheelhouse, Richard T., Wright, Colin W.
• Format: Journal Article
• Language: English
• Published: MALDEN Wiley 01.02.2012
• Subjects: Aldehyde Oxidase - metabolism; Animals; Antimalarials - metabolism; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cryptolepis; Female; Indole Alkaloids - metabolism; Life Sciences & Biomedicine; Liver - enzymology; Magnetic Resonance Spectroscopy; Malaria, Falciparum - drug therapy; Mass Spectrometry; Oxidation-Reduction; Pharmacology & Pharmacy; Plant Roots - chemistry; Plants, Medicinal - chemistry; Plasmodium falciparum; Quinolines - metabolism; Rabbits; Science & Technology; ANALOGS; SANGUINOLENTA; Plasmodium falciparum; XANTHINE-OXIDASE; IN-VITRO; 2-fluorocryptolepine; cryptolepine; PURIFICATION; LIVER; ANTIMALARIAL ACTIVITY; AGENTS; INDOLOQUINOLINE; Cryptolepis sanguinolenta; aldehyde oxidase; ALKALOIDS

Objectives To investigate the metabolism of cryptolepine and some cryptolepine analogues by aldehyde oxidase, and to assess the implications of the results on the potential of cryptolepine analogues as antimalarial agents. Methods The products resulting from the oxidation of cryptolepine and 2-fluor...