Long‐term effects of Pfizer‐BioNTech COVID‐19 vaccinations on platelets

There is a global concern about the safety of COVID‐19 vaccines associated with platelet function. However, their long‐term effects on overall platelet activity remain poorly understood. Here we address this problem by image‐based single‐cell profiling and temporal monitoring of circulating platelet...

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Published inCytometry. Part A Vol. 103; no. 2; pp. 162 - 167
Main Authors Zhou, Yuqi, Nishikawa, Masako, Kanno, Hiroshi, Yang, Ruoxi, Ibayashi, Yuma, Xiao, Ting‐Hui, Peterson, Walker, Herbig, Maik, Nitta, Nao, Miyata, Shigeki, Kanthi, Yogendra, Rohde, Gustavo K., Moriya, Kyoji, Yatomi, Yutaka, Goda, Keisuke
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.02.2023
Wiley Subscription Services, Inc
Subjects
Agglomeration
Blood circulation
Blood Platelets
BNT162 Vaccine
Brief Report
Brief Reports
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Humans
Leukocytes
mRNA vaccine
Platelet aggregation
Platelets
thrombosis
Vaccination - adverse effects
Vaccines
COVID-19
thrombosis
mRNA vaccine
platelet aggregation
Online AccessGet full text
ISSN1552-4922
1552-4930
1552-4930
DOI10.1002/cyto.a.24677

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Abstract There is a global concern about the safety of COVID‐19 vaccines associated with platelet function. However, their long‐term effects on overall platelet activity remain poorly understood. Here we address this problem by image‐based single‐cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer‐BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet‐leukocyte interaction was insignificant.
AbstractList There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet activity remain poorly understood. Here we address this problem by image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant.There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet activity remain poorly understood. Here we address this problem by image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant.
There is a global concern about the safety of COVID‐19 vaccines associated with platelet function. However, their long‐term effects on overall platelet activity remain poorly understood. Here we address this problem by image‐based single‐cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer‐BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet‐leukocyte interaction was insignificant.
There is a global concern about the safety of COVID‐19 vaccines associated with platelet function. However, their long‐term effects on overall platelet activity remain poorly understood. Here we address this problem by image‐based single‐cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer‐BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet‐leukocyte interaction was insignificant.
Author Zhou, Yuqi
Ibayashi, Yuma
Herbig, Maik
Goda, Keisuke
Xiao, Ting‐Hui
Kanno, Hiroshi
Miyata, Shigeki
Nitta, Nao
Rohde, Gustavo K.
Yatomi, Yutaka
Yang, Ruoxi
Nishikawa, Masako
Kanthi, Yogendra
Peterson, Walker
Moriya, Kyoji
AuthorAffiliation 6 Department of Biomedical Engineering University of Virginia Charlottesville Virginia USA
7 Department of Electrical and Computer Engineering University of Virginia Charlottesville Virginia USA
10 Department of Clinical Laboratory Medicine, Graduate School of Medicine The University of Tokyo Tokyo Japan
4 Research and Development Department Central Blood Institute, Japanese Red Cross Society Tokyo Japan
8 Department of Infection Control and Prevention The University of Tokyo Hospital Tokyo Japan
1 Department of Chemistry The University of Tokyo Tokyo Japan
12 Department of Bioengineering University of California Los Angeles California USA
3 CYBO, Inc Tokyo Japan
9 Department of Infectious Diseases The University of Tokyo Hospital Tokyo Japan
2 Department of Clinical Laboratory The University of Tokyo Hospital Tokyo Japan
5 National Heart, Lung, and Blood Institute National Institutes of Health Bethesda Maryland USA
11 Institute of Technological Sciences Wuhan University Wuhan China
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crossref_primary_10_1007_s11239_022_02764_9
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Issue 2
Keywords COVID-19
thrombosis
mRNA vaccine
platelet aggregation
Language English
License 2022 International Society for Advancement of Cytometry.
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
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Funding information Charitable Trust Laboratory Medicine Research Foundation of Japan; Chemo‐Sero‐Therapeutic Research Institute; ImPACT Program; Japan Agency for Medical Research and Development, Grant/Award Number: JP20wm0325021; JSPS KAKENHI, Grant/Award Numbers: 19H05633, 20H00317, 21K15640; JSPS‐NUS/NTU Bilateral Joint Research Program 2021; Konica Minolta Foundation; Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering; Ogasawara Foundation for the Promotion of Science and Engineering; White Rock Foundation; National Institutes of Health, USA, Grant/Award Number: GM130825
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Snippet There is a global concern about the safety of COVID‐19 vaccines associated with platelet function. However, their long‐term effects on overall platelet...
There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet...
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wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 162
SubjectTerms Agglomeration
Blood circulation
Blood Platelets
BNT162 Vaccine
Brief Report
Brief Reports
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Humans
Leukocytes
mRNA vaccine
Platelet aggregation
Platelets
thrombosis
Vaccination - adverse effects
Vaccines
Title Long‐term effects of Pfizer‐BioNTech COVID‐19 vaccinations on platelets
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcyto.a.24677
https://www.ncbi.nlm.nih.gov/pubmed/35938513
https://www.proquest.com/docview/2775498532
https://www.proquest.com/docview/2699957718
https://pubmed.ncbi.nlm.nih.gov/PMC9538905
Volume 103
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