Age-Related Changes in FGF-2, Fibroblast Growth Factor Receptors and β-Catenin Expression in Human Mesenchyme-Derived Progenitor Cells

• Published in: Journal of cellular biochemistry Vol. 117; no. 3; pp. 721 - 729
• Main Authors: Hurley, Marja M., Gronowicz, Gloria, Zhu, Li, Kuhn, Liisa T., Rodner, Craig, Xiao, Liping
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2016
• Subjects: Adult; Aged; AGING; beta Catenin - genetics; beta Catenin - metabolism; Cells, Cultured; ENDOGENOUS FIBROBLAST GROWTH FACTOR-2; Female; Fibroblast Growth Factor 2 - physiology; FIBROBLAST GROWTH FACTOR RECEPTOR; Gene Expression; HUMAN MESENCHYME-DERIVED PROGENITOR CELLS; Humans; Mesenchymal Stromal Cells - metabolism; Middle Aged; Receptor, Fibroblast Growth Factor, Type 1 - genetics; Receptor, Fibroblast Growth Factor, Type 1 - metabolism; Wnt Signaling Pathway; Young Adult; β-CATENIN; AGING; FIBROBLAST GROWTH FACTOR RECEPTOR; ENDOGENOUS FIBROBLAST GROWTH FACTOR-2; β-CATENIN; HUMAN MESENCHYME-DERIVED PROGENITOR CELLS

ABSTRACT FGF‐2 stimulates preosteoblast replication, and knockout of the FGF‐2 gene in mice resulted in osteopenia with age, associated with decreased Wnt–β‐Catenin signaling. In addition, targeted expression of FGF‐2 in osteoblast progenitors increased bone mass in mice via Wnt‐β‐Catenin signaling....