Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects

• Published in: Annals of surgery Vol. 258; no. 4; p. 591
• Main Authors: Simmons, Jon D, Lee, Yann-Leei, Mulekar, Sujata, Kuck, Jamie L, Brevard, Sidney B, Gonzalez, Richard P, Gillespie, Mark N, Richards, William O
• Format: Journal Article
• Language: English
• Published: United States 01.10.2013
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Cohort Studies; Cyclooxygenase 1 - blood; Cyclooxygenase 1 - genetics; DNA, Mitochondrial - blood; Female; Genetic Markers; Humans; Injury Severity Score; Male; Middle Aged; Multiple Organ Failure - blood; Multiple Organ Failure - diagnosis; Multiple Organ Failure - etiology; Multiple Organ Failure - mortality; NADH Dehydrogenase - blood; NADH Dehydrogenase - genetics; Prognosis; Prospective Studies; Real-Time Polymerase Chain Reaction; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - diagnosis; Systemic Inflammatory Response Syndrome - etiology; Systemic Inflammatory Response Syndrome - mortality; Wounds and Injuries - blood; Wounds and Injuries - complications; Wounds and Injuries - mortality

Our objective was to execute a prospective cohort study to determine relationships between plasma mtDNA DAMP levels and the occurrence of systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and mortality. Mitochondrial DNA damage-associated molecular patterns...