Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects - Simmons, Jon D; Lee, Yann-Leei; Mulekar, Sujata; Kuck, Jamie L; Brevard, Sidney B; Gonzalez, Richard P; Gillespie, Mark N; Richards, William O (Annals of surgery, 2013)
Keywords: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Cohort Studies; Cyclooxygenase 1 - blood; Cyclooxygenase 1 - genetics; DNA, Mitochondrial - blood; Female; Genetic Markers; Humans; Injury Severity Score; Male; Middle Aged; Multiple Organ Failure - blood; Multiple Organ Failure - diagnosis; Multiple Organ Failure - etiology; Multiple Organ Failure - mortality; NADH Dehydrogenase - blood; NADH Dehydrogenase - genetics; Prognosis; Prospective Studies; Real-Time Polymerase Chain Reaction; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - diagnosis; Systemic Inflammatory Response Syndrome - etiology; Systemic Inflammatory Response Syndrome - mortality; Wounds and Injuries - blood; Wounds and Injuries - complications; Wounds and Injuries - mortality