Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment

• Published in: Circulation research Vol. 132; no. 10; pp. 1320 - 1337
• Main Author: Chappell, Mark C.
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 12.05.2023
• Subjects: Angiotensin-Converting Enzyme 2 - metabolism; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Compendium on COVID-19 and Cardiovascular Disease; COVID-19; Female; Humans; Male; Peptidyl-Dipeptidase A - physiology; Post-Acute COVID-19 Syndrome; Renin-Angiotensin System - physiology; SARS-CoV-2; Sex Characteristics; SARS-CoV-2; androgen; estrogen; peptidyl-dipeptidase A; angiotensin-converting enzyme 2; renin-angiotensin system

The current epidemic of corona virus disease (COVID-19) has resulted in an immense health burden that became the third leading cause of death and potentially contributed to a decline in life expectancy in the United States. The severe acute respiratory syndrome-related coronavirus-2 binds to the sur...