Dosimetry of fractionated experimental radioimmunotargeting with idiotypic and anti‐idiotypic anticytokeratin antibodies

• Published in: Cancer Vol. 80; no. S12; pp. 2681 - 2688
• Main Authors: Norrlund, Rauni Rossi, Ullén, Anders, Sandström, Per, Holback, Daniel, Johansson, Lennart, Stigbrand, Torgny, Hietala, Sven‐Ola, Åhlström, Katrine Riklund
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York John Wiley & Sons, Inc 15.12.1997; Wiley-Liss
• Subjects: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; anti‐idiotype; Autoradiography; Biological and medical sciences; dosimetry; Female; fractionated; HeLa Hep2; Humans; Iodine Radioisotopes; iodine‐125; Keratins - immunology; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Nude; monoclonal antibody; Neoplasm Transplantation; Neoplasms, Experimental - diagnostic imaging; Neoplasms, Experimental - radiotherapy; Radiation Dosage; Radiation therapy and radiosensitizing agent; Radioimmunodetection; radioimmunotargeting; Transplantation, Heterologous; Treatment with physical agents; Treatment. General aspects; Tumors

BACKGROUND Repeated injections of iodine‐125 (125I)‐labeled tumor targeting anticytokeratin monoclonal antibody (TS1) and a nonlabeled antiidiotypic monoclonal antibody against TS1 (αTS1) were compared with a single injection of the radiolabeled TS1 in experimental radioimmunotargeting. Anti‐TS1 was...