SENP1 regulates cell migration and invasion in neuroblastoma

• Published in: Biotechnology and applied biochemistry Vol. 63; no. 3; p. 435
• Main Authors: Xiang-Ming, Yan, Zhi-Qiang, Xu, Ting, Zhang, Jian, Wang, Jian, Pan, Li-Qun, Yuan, Ming-Cui, Fu, Hong-Liang, Xia, Xu, Cao, Yun, Zhou
• Format: Journal Article
• Language: English
• Published: United States 01.05.2016
• Subjects: Cadherins - genetics; Cell Line, Tumor; Cell Movement; Child, Preschool; Cysteine Endopeptidases; Down-Regulation; Endopeptidases - deficiency; Endopeptidases - genetics; Endopeptidases - metabolism; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Neoplasm Invasiveness; Neoplasm Metastasis; Neuroblastoma - enzymology; Neuroblastoma - genetics; Neuroblastoma - pathology; neuroblastoma; migration and invasion; CDH1; SENP1

Neuroblastoma (NB) is an embryonic solid tumor derived from precursor cells of the sympathetic nervous system, and accounts for 11% of childhood cancers and around 15% of cancer deaths in children. SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectrum of protein activities. The...