Optimal vaccine trial design when estimating vaccine efficacy for susceptibility and infectiousness from multiple populations

• Published in: Statistics in medicine Vol. 17; no. 10; pp. 1121 - 1136
• Main Authors: Longini Jr, Ira M., Sagatelian, Karen, Rida, Wasima N., Halloran, M. Elizabeth
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc., A Wiley Company 30.05.1998; Wiley
• Subjects: Biological and medical sciences; Clinical Trials as Topic - statistics & numerical data; Communicable Disease Control - statistics & numerical data; Disease Susceptibility - epidemiology; Disease Susceptibility - prevention & control; General aspects; Humans; Medical sciences; Models, Statistical; Planification. Prevention (methods). Intervention. Evaluation; Public health. Hygiene; Public health. Hygiene-occupational medicine; Research Design; Risk; Treatment Outcome; Vaccination - statistics & numerical data; Parameter estimation; Efficiency; Infectious risk; Vaccination; Body contact; Statistical estimation; Public health; Contamination; Optimal design

Vaccination can have important indirect effects on the spread of an infectious agent by reducing the level of infectiousness of vaccinees who become infected. To estimate the effect of vaccination on infectiousness, one typically requires data on the contacts between susceptible and infected vaccina...