Parametric modulation of neural activity during face emotion processing in unaffected youth at familial risk for bipolar disorder

• Published in: Bipolar disorders Vol. 16; no. 7; pp. 756 - 763
• Main Authors: Brotman, Melissa A, Deveney, Christen M, Thomas, Laura A, Hinton, Kendra E, Yi, Jennifer Y, Pine, Daniel S, Leibenluft, Ellen
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.11.2014
• Subjects: Adolescent; Analysis of Variance; at risk; bipolar disorder; Bipolar Disorder - pathology; Brain - blood supply; Brain - physiopathology; Brain Mapping; Child; Face; face emotion; Facial Expression; Female; functional magnetic resonance imaging (fMRI); Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Oxygen - blood; parametric modulation; Pattern Recognition, Visual - physiology; Psychiatric Status Rating Scales; Reaction Time - physiology; functional magnetic resonance imaging (fMRI); bipolar disorder; at risk; face emotion; parametric modulation

Objectives Both patients with pediatric bipolar disorder (BD) and unaffected youth at familial risk (AR) for the illness show impairments in face emotion labeling. Few studies, however, have examined brain regions engaged in AR youth when processing emotional faces. Moreover, studies have yet to exp...