Derivation of cutoffs for the Elecsys® amyloid β (1–42) assay in Alzheimer's disease

• Published in: Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 10; no. 1; pp. 698 - 705
• Main Authors: Shaw, Leslie M., Waligorska, Teresa, Fields, Leona, Korecka, Magdalena, Figurski, Michal, Trojanowski, John Q., Eichenlaub, Udo, Wahl, Simone, Quan, Marian, Pontecorvo, Michael J., Lachno, D. Richard, Talbot, Jayne A., Andersen, Scott W., Siemers, Eric R., Dean, Robert A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2018; Elsevier; Wiley
• Subjects: Alzheimer's disease; Amyloid β; Biomarkers; Cerebrospinal fluid; CSF Biomarkers; Cutoff determination; Florbetapir F 18 imaging; Immunoassay; Method comparison; Patient selection; Immunoassay; Amyloid β; Biomarkers; Method comparison; Cutoff determination; Cerebrospinal fluid; Alzheimer's disease; Patient selection; Florbetapir F 18 imaging

An Elecsys® Amyloid β (Aβ [1–42]) immunoassay cutoff for classification of patients with Alzheimer's disease was investigated. Cerebrospinal fluid samples collected from patients with mild-to-moderate Alzheimer's disease were analyzed by Elecsys® immunoassays: (1) Aβ (1–42), (2) total tau,...