IL‐7 and procalcitonin are useful biomarkers in the comprehensive evaluation of the severity of acute cholangitis
Background The incidence of biliary tract infection (BTI), especially healthcare‐associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers. Methods We retrospectively meas...
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Published in | Journal of hepato-biliary-pancreatic sciences Vol. 24; no. 2; pp. 81 - 88 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Japan
Wiley Subscription Services, Inc
01.02.2017
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Abstract | Background
The incidence of biliary tract infection (BTI), especially healthcare‐associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers.
Methods
We retrospectively measured 11 cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of 61 samples with acute cholangitis.
Result
The 28‐day mortality rate was 9.8%. The levels of most cytokines and chemokines were significantly correlated with each other. A low IL‐7 level was found to predict blood culture positivity. Low IL‐7 level was also found to predict disseminated intravascular coagulation. Low IL‐7 levels and a high PCT level were found to be predictors of severe cholangitis. The 28‐day mortality in the group of patients with an IL‐7 level of ≤6.0 and a PCT level of >0.5 was 18.2%. It was significantly higher than in the other group.
Conclusion
The combined use of IL‐7 and PCT may be useful for evaluating severe acute cholangitis; these results may suggest that severe acute cholangitis is affected by immunosuppressive changes.
HighlightSuwa and colleagues demonstrated that low IL‐7 levels predicted blood culture positivity and disseminated intravascular coagulation in acute cholangitis. Low IL‐7 levels and high procalcitonin levels were found to be predictors of severe cholangitis. The 28‐day mortality was significantly high in the group with low IL‐7 and high procalcitonin levels. |
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AbstractList | Background
The incidence of biliary tract infection (BTI), especially healthcare‐associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers.
Methods
We retrospectively measured 11 cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of 61 samples with acute cholangitis.
Result
The 28‐day mortality rate was 9.8%. The levels of most cytokines and chemokines were significantly correlated with each other. A low IL‐7 level was found to predict blood culture positivity. Low IL‐7 level was also found to predict disseminated intravascular coagulation. Low IL‐7 levels and a high PCT level were found to be predictors of severe cholangitis. The 28‐day mortality in the group of patients with an IL‐7 level of ≤6.0 and a PCT level of >0.5 was 18.2%. It was significantly higher than in the other group.
Conclusion
The combined use of IL‐7 and PCT may be useful for evaluating severe acute cholangitis; these results may suggest that severe acute cholangitis is affected by immunosuppressive changes.
HighlightSuwa and colleagues demonstrated that low IL‐7 levels predicted blood culture positivity and disseminated intravascular coagulation in acute cholangitis. Low IL‐7 levels and high procalcitonin levels were found to be predictors of severe cholangitis. The 28‐day mortality was significantly high in the group with low IL‐7 and high procalcitonin levels. Background The incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers. Methods We retrospectively measured 11 cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of 61 samples with acute cholangitis. Result The 28-day mortality rate was 9.8%. The levels of most cytokines and chemokines were significantly correlated with each other. A low IL-7 level was found to predict blood culture positivity. Low IL-7 level was also found to predict disseminated intravascular coagulation. Low IL-7 levels and a high PCT level were found to be predictors of severe cholangitis. The 28-day mortality in the group of patients with an IL-7 level of ≤6.0 and a PCT level of >0.5 was 18.2%. It was significantly higher than in the other group. Conclusion The combined use of IL-7 and PCT may be useful for evaluating severe acute cholangitis; these results may suggest that severe acute cholangitis is affected by immunosuppressive changes. The incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers. We retrospectively measured 11 cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of 61 samples with acute cholangitis. The 28-day mortality rate was 9.8%. The levels of most cytokines and chemokines were significantly correlated with each other. A low IL-7 level was found to predict blood culture positivity. Low IL-7 level was also found to predict disseminated intravascular coagulation. Low IL-7 levels and a high PCT level were found to be predictors of severe cholangitis. The 28-day mortality in the group of patients with an IL-7 level of ≤6.0 and a PCT level of >0.5 was 18.2%. It was significantly higher than in the other group. The combined use of IL-7 and PCT may be useful for evaluating severe acute cholangitis; these results may suggest that severe acute cholangitis is affected by immunosuppressive changes. BACKGROUNDThe incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers.METHODSWe retrospectively measured 11 cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of 61 samples with acute cholangitis.RESULTThe 28-day mortality rate was 9.8%. The levels of most cytokines and chemokines were significantly correlated with each other. A low IL-7 level was found to predict blood culture positivity. Low IL-7 level was also found to predict disseminated intravascular coagulation. Low IL-7 levels and a high PCT level were found to be predictors of severe cholangitis. The 28-day mortality in the group of patients with an IL-7 level of ≤6.0 and a PCT level of >0.5 was 18.2%. It was significantly higher than in the other group.CONCLUSIONThe combined use of IL-7 and PCT may be useful for evaluating severe acute cholangitis; these results may suggest that severe acute cholangitis is affected by immunosuppressive changes. Abstract Background The incidence of biliary tract infection ( BTI ), especially healthcare‐associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers. Methods We retrospectively measured 11 cytokines, six chemokines and procalcitonin ( PCT ), and endotoxin activity assay ( EAA ) values ( IRB : 110512019) of 61 samples with acute cholangitis. Result The 28‐day mortality rate was 9.8%. The levels of most cytokines and chemokines were significantly correlated with each other. A low IL ‐7 level was found to predict blood culture positivity. Low IL ‐7 level was also found to predict disseminated intravascular coagulation. Low IL ‐7 levels and a high PCT level were found to be predictors of severe cholangitis. The 28‐day mortality in the group of patients with an IL ‐7 level of ≤6.0 and a PCT level of >0.5 was 18.2%. It was significantly higher than in the other group. Conclusion The combined use of IL ‐7 and PCT may be useful for evaluating severe acute cholangitis; these results may suggest that severe acute cholangitis is affected by immunosuppressive changes. |
Author | Kumamoto, Takafumi Mori, Ryutaro Kadokura, Toshiaki Suwa, Yusuke Endo, Itaru Goto, Koki Matsuyama, Ryusei Miyasho, Taku Sato, Mari Taguri, Masataka |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28002647$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_4291_wjgp_v9_i1_1 crossref_primary_10_3390_medicina58020255 crossref_primary_10_1016_j_jviscsurg_2019_05_007 crossref_primary_10_1016_j_jchirv_2019_02_009 crossref_primary_10_3390_jcm11051155 crossref_primary_10_1016_j_gtc_2021_02_005 crossref_primary_10_1139_gen_2017_0074 crossref_primary_10_1155_2020_8203813 crossref_primary_10_2147_IJGM_S416108 crossref_primary_10_2169_internalmedicine_0945_22 crossref_primary_10_1186_s13099_023_00587_4 crossref_primary_10_1016_j_hbpd_2023_08_005 crossref_primary_10_15279_kpba_2022_27_2_81 crossref_primary_10_1016_j_jss_2023_07_047 crossref_primary_10_1590_s0004_2803_202202000_39 |
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Keywords | Endotoxin activity assay Cytokines Interleukin-7 Acute cholangitis Procalcitonin |
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The incidence of biliary tract infection (BTI), especially healthcare‐associated cholangitis, is increasing. However, there are few reports... The incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports concerning... Abstract Background The incidence of biliary tract infection ( BTI ), especially healthcare‐associated cholangitis, is increasing. However, there are few... Background The incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports... BACKGROUNDThe incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports... |
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SubjectTerms | Acute cholangitis Acute Disease Adult Aged Aged, 80 and over Biomarkers Biomarkers - blood Calcitonin - blood Chemokines Cholangitis - blood Cholangitis - diagnosis Cholangitis - immunology Cytokines Cytokines - blood Endotoxin activity assay Endotoxins - blood Endotoxins - immunology Female Humans Interleukin-7 - blood Interleukin‐7 Male Middle Aged Procalcitonin Retrospective Studies |
Title | IL‐7 and procalcitonin are useful biomarkers in the comprehensive evaluation of the severity of acute cholangitis |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjhbp.420 https://www.ncbi.nlm.nih.gov/pubmed/28002647 https://www.proquest.com/docview/1870062196/abstract/ https://search.proquest.com/docview/1851695076 |
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