Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish

• Published in: Circulation research Vol. 109; no. 6; pp. 658 - 669
• Main Authors: Ding, Yonghe, Sun, Xiaojing, Huang, Wei, Hoage, Tiffany, Redfield, Margaret, Kushwaha, Sudhir, Sivasubbu, Sridhar, Lin, Xueying, Ekker, Stephen, Xu, Xiaolei
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 02.09.2011; Lippincott Williams & Wilkins
• Subjects: Aging - genetics; Anemias. Hemoglobinopathies; Animals; Animals, Genetically Modified; Biological and medical sciences; Cardiology. Vascular system; Cardiomyopathies - enzymology; Cardiomyopathies - genetics; Cardiomyopathies - prevention & control; Cells, Cultured; Danio rerio; Disease Models, Animal; Diseases of red blood cells; Freshwater; Fundamental and applied biological sciences. Psychology; Haploinsufficiency - genetics; Heart; Hematologic and hematopoietic diseases; Medical sciences; Myocarditis. Cardiomyopathies; TOR Serine-Threonine Kinases - biosynthesis; TOR Serine-Threonine Kinases - deficiency; TOR Serine-Threonine Kinases - genetics; Vertebrates: cardiovascular system; Zebrafish; Zebrafish Proteins - biosynthesis; Zebrafish Proteins - deficiency; Zebrafish Proteins - genetics; Sirolimus; Cardiomyopathy; Cardiovascular disease; Hemopathy; Myocardial disease; Doxorubicin; Macrocycle; Isomerases; Heart disease; Pisces; Adult; Protein synthesis inhibitor; Human; DNA topoisomerase (ATP-hydrolysing); Enzyme; Anemia; Enzyme inhibitor; Lactone; Topoisomerase II inhibitor; Macrolide; Vertebrata; Brachydanio rerio; cardiotoxicity; Mammalia; Anthracyclins; Circulatory system; target of rapamycin; zebrafish

RATIONALE:Although a cardioprotective function of target of rapamycin (TOR) signaling inhibition has been suggested by pharmacological studies using rapamycin, genetic evidences are still lacking. We explored adult zebrafish as a novel vertebrate model for dissecting signaling pathways in cardiomyop...