Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner

• Published in: EMBO reports Vol. 15; no. 12; pp. 1268 - 1277
• Main Authors: Bremm, Anja, Moniz, Sonia, Mader, Julia, Rocha, Sonia, Komander, David
• Format: Journal Article
• Language: English
• Published: London Blackwell Publishing Ltd 01.12.2014; Nature Publishing Group UK; BlackWell Publishing Ltd
• Subjects: Animals; Apoptosis - physiology; Cell Line; Cezanne; EMBO31; EMBO37; Endopeptidases - genetics; Endopeptidases - metabolism; HeLa Cells; HIF-1α; Humans; hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Immunoprecipitation; Lys11-linked ubiquitin chains; Mice; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Protein Binding; Real-Time Polymerase Chain Reaction; Scientific Report; ubiquitin; hypoxia; HIF‐1α; Lys11‐linked ubiquitin chains; Cezanne; ubiquitin

The transcription factor HIF‐1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF‐1α is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF‐1α homeostasis. Loss of Cezanne decreases...