An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model - Livezey, Jeffrey; Twomey, Patrick; Morrison, Meshell; Cicatelli, Susan; Duncan, Elizabeth H.; Hamer, Melinda; Lee, Christine; Hutter, Jack; Mills, Kristin; DeLuca, Jesse; Poon, Lucas; Selig, Daniel; et al. (Malaria journal, 2020)
Keywords: Adult; Antibiotics; Antimalarials - adverse effects; Aquatic insects; Armed forces; Azithromycin; Azithromycin - adverse effects; Biomedical and Life Sciences; Biomedicine; Birth control; Chemical kinetics; Chloroquine; Chloroquine - adverse effects; Clinical trials; Compliance; Contraindications; Controlled human malaria infection; Disease prophylaxis; Dosage; Dosage and administration; Drug Combinations; Drug dosages; Drug Resistance; Drug therapy; Electrocardiography; Entomology; Female; Human diseases; Humans; Infections; Infectious Diseases; Laboratories; Malaria; Malaria chemoprophylaxis; Malaria, Falciparum - drug therapy; Male; Methods; Microbiology; Middle Aged; Military operations; Mosquitoes; Nausea; Parasites; Parasitology; Pharmacokinetics; Plasmodium falciparum; Plasmodium falciparum - drug effects; Pregnancy; Prophylaxis; Public Health; Side effects; Symptoms; Tropical Medicine; Vector-borne diseases; Weekly; Young Adult; United States; Colombia; Suriname; United States--US; India; Malaria chemoprophylaxis; Controlled human malaria infection; Chloroquine; Azithromycin