Increased vascular O-GlcNAcylation augments reactivity to constrictor stimuli — Vasoactive Peptide Symposium

• Published in: Journal of the American Society of Hypertension Vol. 2; no. 6; pp. 410 - 417
• Main Authors: Lima, Victor V, Giachini, Fernanda R.C., MSc, Carneiro, Fernando S., MSc, Carneiro, Zidonia N, Fortes, Zuleica B., PhD, Carvalho, Maria Helena C., PhD, Webb, R. Clinton, PhD, Tostes, Rita C., PhD
• Format: Journal Article
• Language: English
• Published: United States 01.11.2008
• Subjects: Cardiovascular; potassium chloride; eNOS; PugNAc; phosphoinositide-3 kinase; vascular reactivity; O-Linked N-acetylglucosaminylation (O-GlcNAc)

Abstract O-linked N-acetylglucosaminylation (O-GlcNAcylation) plays a role in many aspects of protein function. Whereas elevated O-GlcNAc levels contribute to diabetes-related end-organ damage, O-GlcNAcylation is also physiologically important. Because proteins that play a role in vascular tone regu...