Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population

In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population....

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Published inGenetics and molecular biology Vol. 35; no. 2; pp. 413 - 417
Main Authors Alami, Faranak Mahmoudi, Ahmadi, Mehran, Bazrafshan, Hamidreza, Tabarraei, Alijan, Khosravi, Ayyoob, Tabatabaiefar, Mohammad Amin, Samaei, Nader Mansour
Format Journal Article
LanguageEnglish
Published Brazil Sociedade Brasileira de Genética 01.01.2012
Subjects
BIOCHEMISTRY & MOLECULAR BIOLOGY
GENETICS & HEREDITY
Human and Medical Genetics
rs12255372 variant
single nucleotide polymorphism (SNP)
TCF7L2 gene
type 2 diabetes mellitus (T2DM)
rs12255372 variant
TCF7L2 gene
single nucleotide polymorphism (SNP)
type 2 diabetes mellitus (T2DM)
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Abstract In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108-1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147-3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05-2.21) p = 0.026)] and 1.74 [95% CI (1.01-3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM.
AbstractList In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108-1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147-3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05-2.21) p = 0.026)] and 1.74 [95% CI (1.01-3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM.
In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108–1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147–3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05–2.21) p = 0.026)] and 1.74 [95% CI (1.01–3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM.
Author Alami, Faranak Mahmoudi
Bazrafshan, Hamidreza
Khosravi, Ayyoob
Ahmadi, Mehran
Tabarraei, Alijan
Tabatabaiefar, Mohammad Amin
Samaei, Nader Mansour
AuthorAffiliation 2 Mazandaran University of Medical Sciences, Sari, Iran
1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
6 Biochemistry and Metabolic Disorders Research Center, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran
5 Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Endocrinology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
4 Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran
AuthorAffiliation_xml – name: 2 Mazandaran University of Medical Sciences, Sari, Iran
– name: 6 Biochemistry and Metabolic Disorders Research Center, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran
– name: 4 Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran
– name: 5 Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
– name: 3 Department of Endocrinology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
– name: 1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
– name: Ahvaz Jundishapur University of Medical Sciences
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Issue 2
Keywords rs12255372 variant
TCF7L2 gene
single nucleotide polymorphism (SNP)
type 2 diabetes mellitus (T2DM)
Language English
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Snippet In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus...
In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus...
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SubjectTerms BIOCHEMISTRY & MOLECULAR BIOLOGY
GENETICS & HEREDITY
Human and Medical Genetics
rs12255372 variant
single nucleotide polymorphism (SNP)
TCF7L2 gene
type 2 diabetes mellitus (T2DM)
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Title Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population
URI https://www.ncbi.nlm.nih.gov/pubmed/22888288
https://search.proquest.com/docview/1033457304
https://pubmed.ncbi.nlm.nih.gov/PMC3389527
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300005&lng=en&tlng=en
https://doaj.org/article/05aa9afeed1e47969161c88fe3bbc4e9
Volume 35
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