Diagnostic performance of non-invasive, stool-based molecular assays in patients with paucibacillary tuberculosis

• Published in: Scientific reports Vol. 10; no. 1; p. 7102
• Main Authors: Gaur, Mohita, Singh, Anoop, Sharma, Vishal, Tandon, Gayatri, Bothra, Ankur, Vasudeva, Aarushi, Kedia, Shreeya, Khanna, Ashwani, Khanna, Vishal, Lohiya, Sheelu, Varma-Basil, Mandira, Chaudhry, Anil, Misra, Richa, Singh, Yogendra
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.04.2020; Nature Publishing Group
• Subjects: 38/77; 45/77; 692/699/255/1318; 692/699/255/1856; Adolescent; Adult; Child; Child, Preschool; Deoxyribonucleic acid; DNA; Feces - microbiology; Female; Humanities and Social Sciences; Humans; India; Infant; Infant, Newborn; Lymph nodes; Male; Middle Aged; multidisciplinary; Mycobacterium tuberculosis; Patients; Pleural effusion; Polymerase chain reaction; Science; Science (multidisciplinary); Tuberculosis; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - microbiology; India

Timely diagnosis of paucibacillary tuberculosis (TB) which includes smear-negative pulmonary TB (PTB) and extra-pulmonary TB (EPTB) remains a challenge. This study was performed to assess the diagnostic utility of stool as a specimen of choice for detection of mycobacterial DNA in paucibacillary TB...