Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

• Published in: Acta pharmaceutica Sinica. B Vol. 13; no. 4; pp. 1429 - 1437
• Main Authors: Butowska, Kamila, Han, Xuexiang, Gong, Ningqiang, El-Mayta, Rakan, Haley, Rebecca M., Xue, Lulu, Zhong, Wenqun, Guo, Wei, Wang, Karin, Mitchell, Michael J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2023; Elsevier
• Subjects: Bcl-2; Chemotherapy; Doxorubicin; Lipid nanoparticles; Lymphoma; Original; siRNA delivery; Bcl-2; siRNA delivery; Chemotherapy; Doxorubicin; Lymphoma; Lipid nanoparticles

Evasion of apoptosis is a hallmark of cancer, attributed in part to overexpression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). In a variety of cancer types, including lymphoma, Bcl-2 is overexpressed. Therapeutic targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subj...