Increasing target engagement via customized electrode positioning for personalized transcranial electrical stimulation: A biophysical modeling study

• Published in: NeuroImage (Orlando, Fla.) Vol. 311; p. 121206
• Main Authors: Rodgers, Griffin, Joodaki, Mahyar, Hopf, Alois, Santarnecchi, Emiliano, Guzman, Raphael, Müller, Bert, Osmani, Bekim
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2025; Elsevier Limited; Elsevier
• Subjects: 3D-printing; Adult; Alzheimer's disease; Biophysical modeling; Electric fields; Electrical stimuli; Electrode positioning; Electrodes; Female; Humans; Male; Models, Neurological; Neurodegenerative diseases; Neuroimaging; Neurological diseases; Neuromodulation; Optimization; Parietal Lobe - physiology; Printing, Three-Dimensional; Simulation; Target engagement; Transcranial Direct Current Stimulation - instrumentation; Transcranial Direct Current Stimulation - methods; Transcranial electrical stimulation; Basel Switzerland; Switzerland; Biophysical modeling; Target engagement; Electrode positioning; 3D-printing; Transcranial electrical stimulation

•Digital design and 3D printing of TES caps could allow for flexible positioning of stimulation electrodes.•We provide an in silico proof-of-concept that more flexible positioning significantly increases target engagement.•Personalized optimization with >64 available electrode positions outperfor...