The scientific revolution that unraveled the astonishing DNA repair capacity of the Deinococcaceae : 40 years on

• Published in: Canadian journal of microbiology Vol. 69; no. 10; pp. 369 - 386
• Main Author: Daly, Michael J
• Format: Journal Article
• Language: English
• Published: Canada NRC Research Press 01.10.2023; Canadian Science Publishing NRC Research Press
• Subjects: Antioxidants; Biotechnology; Coupling; Deinococcus; Deoxyribonucleic acid; Desiccation; DNA; DNA damage; DNA repair; Double-strand break repair; Genetic aspects; Genomes; Gram-positive bacteria; Holliday junctions; Metabolism; Metabolites; Microbiological research; Oxidative stress; Polyploidy; Proteomes; Radiation; Radiation tolerance; Radiobiology; Survivability; Survival; United States; Holliday junction; Mn antioxidant; Deinococcus; electron paramagnetic resonance; radiation; DNA repair

The family exhibits exceptional radiation resistance and possesses all the necessary traits for surviving in radiation-exposed environments. Their survival strategy involves the coupling of metabolic and DNA repair functions, resulting in an extraordinarily efficient homologous repair of DNA double-...