The nasal microbiome mirrors and potentially shapes olfactory function

Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, ide...

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Published inScientific reports Vol. 8; no. 1; pp. 1296 - 11
Main Authors Koskinen, Kaisa, Reichert, Johanna L., Hoier, Stefan, Schachenreiter, Jochen, Duller, Stefanie, Moissl-Eichinger, Christine, Schöpf, Veronika
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.01.2018
Nature Publishing Group
Subjects
38/22
38/23
38/77
631/326/2565/2134
631/326/41
Actinobacteria - classification
Actinobacteria - genetics
Actinobacteria - isolation & purification
Actinobacteria - metabolism
Adolescent
Adult
Archaea - classification
Archaea - genetics
Archaea - isolation & purification
Archaea - metabolism
Bacteroidetes - classification
Bacteroidetes - genetics
Bacteroidetes - isolation & purification
Bacteroidetes - metabolism
Butyric acid
Butyric Acid - metabolism
Community composition
Female
Firmicutes - classification
Firmicutes - genetics
Firmicutes - isolation & purification
Firmicutes - metabolism
Healthy Volunteers
Humanities and Social Sciences
Humans
Male
Microbiomes
Microbiota - genetics
Microorganisms
Middle Aged
multidisciplinary
Nasal Cavity - microbiology
Nasal Cavity - physiology
Nose
Odor thresholds
Odorants - analysis
Olfaction
Olfactory discrimination
Olfactory discrimination learning
Olfactory epithelium
Olfactory Mucosa - microbiology
Olfactory Mucosa - physiology
Olfactory Perception - physiology
Olfactory thresholds
Proteobacteria - classification
Proteobacteria - genetics
Proteobacteria - isolation & purification
Proteobacteria - metabolism
RNA, Ribosomal, 16S - genetics
Science
Science (multidisciplinary)
Sensory Thresholds - physiology
Smell
Smell - physiology
Well being
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Abstract Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, identification) and nasal microbiome in 67 healthy volunteers. Twenty-eight subjects were found to have normal olfactory function, 29 had a particularly good sense of smell (“good normosmics”) and 10 were hyposmic. Microbial community composition differed significantly between the three olfactory groups. In particular, butyric acid-producing microorganisms were found to be associated with impaired olfactory function. We describe the first insights of the potential interplay between the olfactory epithelium microbial community and olfactory function, and suggest that the microbiome composition is able to mirror and potentially shape olfactory function by producing strong odor compounds.
AbstractList Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, identification) and nasal microbiome in 67 healthy volunteers. Twenty-eight subjects were found to have normal olfactory function, 29 had a particularly good sense of smell (“good normosmics”) and 10 were hyposmic. Microbial community composition differed significantly between the three olfactory groups. In particular, butyric acid-producing microorganisms were found to be associated with impaired olfactory function. We describe the first insights of the potential interplay between the olfactory epithelium microbial community and olfactory function, and suggest that the microbiome composition is able to mirror and potentially shape olfactory function by producing strong odor compounds.
Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, identification) and nasal microbiome in 67 healthy volunteers. Twenty-eight subjects were found to have normal olfactory function, 29 had a particularly good sense of smell ("good normosmics") and 10 were hyposmic. Microbial community composition differed significantly between the three olfactory groups. In particular, butyric acid-producing microorganisms were found to be associated with impaired olfactory function. We describe the first insights of the potential interplay between the olfactory epithelium microbial community and olfactory function, and suggest that the microbiome composition is able to mirror and potentially shape olfactory function by producing strong odor compounds.Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is involved in normal olfactory epithelium development, we explored the relationship between olfactory function (odor threshold, discrimination, identification) and nasal microbiome in 67 healthy volunteers. Twenty-eight subjects were found to have normal olfactory function, 29 had a particularly good sense of smell ("good normosmics") and 10 were hyposmic. Microbial community composition differed significantly between the three olfactory groups. In particular, butyric acid-producing microorganisms were found to be associated with impaired olfactory function. We describe the first insights of the potential interplay between the olfactory epithelium microbial community and olfactory function, and suggest that the microbiome composition is able to mirror and potentially shape olfactory function by producing strong odor compounds.
ArticleNumber 1296
Author Hoier, Stefan
Koskinen, Kaisa
Moissl-Eichinger, Christine
Reichert, Johanna L.
Schöpf, Veronika
Schachenreiter, Jochen
Duller, Stefanie
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  organization: Hanusch Krankenhaus Vienna, Department of Otorhinolaryngology, Head and Neck Surgery
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  organization: BioTechMed-Graz, Institute of Psychology, University of Graz
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Snippet Olfactory function is a key sense for human well-being and health, with olfactory dysfunction having been linked to serious diseases. As the microbiome is...
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SubjectTerms 38/22
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631/326/2565/2134
631/326/41
Actinobacteria - classification
Actinobacteria - genetics
Actinobacteria - isolation & purification
Actinobacteria - metabolism
Adolescent
Adult
Archaea - classification
Archaea - genetics
Archaea - isolation & purification
Archaea - metabolism
Bacteroidetes - classification
Bacteroidetes - genetics
Bacteroidetes - isolation & purification
Bacteroidetes - metabolism
Butyric acid
Butyric Acid - metabolism
Community composition
Female
Firmicutes - classification
Firmicutes - genetics
Firmicutes - isolation & purification
Firmicutes - metabolism
Healthy Volunteers
Humanities and Social Sciences
Humans
Male
Microbiomes
Microbiota - genetics
Microorganisms
Middle Aged
multidisciplinary
Nasal Cavity - microbiology
Nasal Cavity - physiology
Nose
Odor thresholds
Odorants - analysis
Olfaction
Olfactory discrimination
Olfactory discrimination learning
Olfactory epithelium
Olfactory Mucosa - microbiology
Olfactory Mucosa - physiology
Olfactory Perception - physiology
Olfactory thresholds
Proteobacteria - classification
Proteobacteria - genetics
Proteobacteria - isolation & purification
Proteobacteria - metabolism
RNA, Ribosomal, 16S - genetics
Science
Science (multidisciplinary)
Sensory Thresholds - physiology
Smell
Smell - physiology
Well being
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Title The nasal microbiome mirrors and potentially shapes olfactory function
URI https://link.springer.com/article/10.1038/s41598-018-19438-3
https://www.ncbi.nlm.nih.gov/pubmed/29358754
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Volume 8
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