Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy - Martin, Jerome C.; Chang, Christie; Boschetti, Gilles; Ungaro, Ryan; Giri, Mamta; Grout, John A.; Gettler, Kyle; Chuang, Ling-shiang; Nayar, Shikha; Greenstein, Alexander J.; Dubinsky, Marla; Walker, Laura; et al. (Cell, 2019)
Keywords: biomarkers; blood plasma; Crohn disease; Crohn Disease - immunology; Crohn Disease - pathology; Crohn Disease - therapy; Crohn’s disease; cytokines; Cytokines - immunology; high-dimensional profiling; Humans; immunoglobulin G; Immunotherapy - methods; inflammatory bowel disease; Intestines - pathology; Life Sciences; molecular classification; patients; phagocytes; Phagocytes - pathology; plasma cells; remission; Single-Cell Analysis; single-cell RNA sequencing; stromal cells; Stromal Cells - pathology; T-lymphocytes; T-Lymphocytes - pathology; therapeutics; Tumor Necrosis Factor-alpha - antagonists & inhibitors; single-cell RNA sequencing; inflammatory bowel disease; high-dimensional profiling; molecular classification; Crohn’s disease