Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells
We have previously shown that angiomotin (Amot) plays an important role in growth factor-induced migration of endothelial cells in vitro. Genetic knock-down of Amot in zebrafish also results in inhibition of migration of intersegmental vessels in vivo. Amot is expressed as two different isoforms, p8...
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Published in | Biochimica et biophysica acta Vol. 1783; no. 3; pp. 429 - 437 |
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Main Authors | , , , , , , |
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Language | English |
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Elsevier B.V
01.03.2008
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Abstract | We have previously shown that angiomotin (Amot) plays an important role in growth factor-induced migration of endothelial cells in vitro. Genetic knock-down of Amot in zebrafish also results in inhibition of migration of intersegmental vessels in vivo. Amot is expressed as two different isoforms, p80-Amot and p130-Amot. Here we have analyzed the expression of the two Amot isoforms during retinal angiogenesis in vivo and demonstrate that p80-Amot is expressed during the migratory phase. In contrast, p130-Amot is expressed during the period of blood vessel stabilization and maturation. We also show that the N-terminal domain of p130-Amot serves as a targeting domain responsible for localization of p130-Amot to actin and tight junctions. We further show that the relative expression levels of p80-Amot and p130-Amot regulate a switch between a migratory and a non-migratory cell phenotype where the migratory function of p80-Amot is dominant over the stabilization and maturation function of p130-Amot. Our data indicates that homo-oligomerization of p80-Amot and hetero-oligomerization of both isoforms are critical for this regulation. |
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AbstractList | We have previously shown that angiomotin (Amot) plays an important role in growth factor-induced migration of endothelial cells in vitro. Genetic knock-down of Amot in zebrafish also results in inhibition of migration of intersegmental vessels in vivo. Amot is expressed as two different isoforms, p80-Amot and p130-Amot. Here we have analyzed the expression of the two Amot isoforms during retinal angiogenesis in vivo and demonstrate that p80-Amot is expressed during the migratory phase. In contrast, p130-Amot is expressed during the period of blood vessel stabilization and maturation. We also show that the N-terminal domain of p130-Amot serves as a targeting domain responsible for localization of p130-Amot to actin and tight junctions. We further show that the relative expression levels of p80-Amot and p130-Amot regulate a switch between a migratory and a non-migratory cell phenotype where the migratory function of p80-Amot is dominant over the stabilization and maturation function of p130-Amot. Our data indicates that homo-oligomerization of p80-Amot and hetero-oligomerization of both isoforms are critical for this regulation. |
Author | Veitonmaki, Niina Ernkvist, Mira Sinha, Indranil Nyström, Staffan Aase, Karin Holmgren, Lars Birot, Olivier |
Author_xml | – sequence: 1 givenname: Mira surname: Ernkvist fullname: Ernkvist, Mira – sequence: 2 givenname: Olivier surname: Birot fullname: Birot, Olivier – sequence: 3 givenname: Indranil surname: Sinha fullname: Sinha, Indranil – sequence: 4 givenname: Niina surname: Veitonmaki fullname: Veitonmaki, Niina – sequence: 5 givenname: Staffan surname: Nyström fullname: Nyström, Staffan – sequence: 6 givenname: Karin surname: Aase fullname: Aase, Karin – sequence: 7 givenname: Lars surname: Holmgren fullname: Holmgren, Lars email: lars.holmgren@ki.se |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18164266$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:116753188$$DView record from Swedish Publication Index |
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SubjectTerms | Actin Angiogenesis Animals Animals, Newborn Calcium switch Cell Adhesion - physiology Cell Communication - physiology Cell Movement - physiology Cells, Cultured CHO Cells Cricetinae Cricetulus Dimerization Dogs Endothelial Cells - metabolism Endothelial Cells - physiology Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - physiology Medicin och hälsovetenskap Mice Microfilament Proteins - metabolism Microfilament Proteins - physiology Neovascularization, Physiologic - physiology Protein Binding Protein Isoforms - metabolism Protein Isoforms - physiology Protein Transport Retina Retinal Vessels - growth & development Retinal Vessels - metabolism Tight junction |
Title | Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells |
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