Gelatin Nanoparticles for Complexation and Enhanced Cellular Delivery of mRNA

• Published in: Nanomaterials (Basel, Switzerland) Vol. 12; no. 19; p. 3423
• Main Authors: Andrée, Lea, Oude Egberink, Rik, Dodemont, Josephine, Hassani Besheli, Negar, Yang, Fang, Brock, Roland, Leeuwenburgh, Sander C. G.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.09.2022; MDPI
• Subjects: Biocompatibility; Biological products; Biomaterials; Biomedical materials; Complexation; Confocal microscopy; endosomal escape; Ethylenediaminetetraacetic acid; Fluorescence; Gelatin; gelatin nanoparticles; Gene expression; Growth factors; Hydrogels; Lipids; Messenger RNA; Morphology; mRNA; mRNA delivery; Nanomaterials; Nanoparticles; Nanotechnology; Physiology; Polymers; Proteins; Regenerative medicine; RNA transport; Surface charge; Vaccination; Vectors (Biology); United States; Netherlands; Belgium; United States > US
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano12193423

Messenger RNA (mRNA) is increasingly gaining interest as a modality in vaccination and protein replacement therapy. In regenerative medicine, the mRNA-mediated expression of growth factors has shown promising results. In contrast to protein delivery, successful mRNA delivery requires a vector to ind...