Something old, something new: revisiting natural products in antibiotic drug discovery
Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory cha...
Saved in:
| Published in | Canadian journal of microbiology Vol. 60; no. 3; pp. 147 - 154 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Canada
NRC Research Press
01.03.2014
Canadian Science Publishing NRC Research Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0008-4166 1480-3275 1480-3275 |
| DOI | 10.1139/cjm-2014-0063 |
Cover
Loading…
| Abstract | Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an “apocalyptic” threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis. |
|---|---|
| AbstractList | Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi- antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an "apocalyptic" threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis. Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi- antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an "apocalyptic" threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis. Key words: actinomycetes, antibiotic, synthetic biology, genome. La decouverte d'antibiotiques est en situation de crise. En depit de la demande croissante de nouveaux medicaments decoulant du nombre sans cesse grandissant de pathogenes multiresistants, seule une poignee de nouveaux antibiotiques a ete approuvee pour usage clinique ces 20 dernieres annees. Confronte a des difficultes scientifiques, economiques et reglementaires, le milieu pharmaceutique semble incapable de reagir a une menace qu'on qualifie d'<< apocalyptique >>. Les produits naturels synthetises par les bacteries et les champignons sont des produits de la selection naturelle codes genetiquement qui ont fourni l'essentiel des sources d'antibiotiques actuellement en usage clinique. L'industrie pharmaceutique a generalement abandonne ces substances au profit de vastes banques de molecules synthetiques, en raison de difficultes dans l'identification de nouvelles structures moleculaires naturelles aux proprietes antibiotiques. Les avancees en matiere de sequen^age genomique de nouvelle generation, de bio-informatique et de chimie analytique s'allient dans le but de surmonter les obstacles entourant les produits naturels. Conjugues a de nouvelles strategies de decouverte d'antibiotiques, dont l'inhibition de la resistance, les nouveaux agencements medicamenteux et les nouvelles cibles, les produits naturels sont a l'aube d'une renaissance qui viendra denouer la crise qui secoue la sante. [Traduit par la Redaction] Mots-cles: actinomycetes, antibiotique, biologie de synthese, genome. Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an "apocalyptic" threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis. [PUBLICATION ABSTRACT] Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an "apocalyptic" threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis.Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an "apocalyptic" threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis. |
| Audience | Academic |
| Author | Wright, Gerard D. |
| Author_xml | – sequence: 1 givenname: Gerard D. surname: Wright fullname: Wright, Gerard D. organization: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24588388$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVks1v1DAQxS1URLcLR64oggtIpNjxR7y9VVWBShVIFLhaE2eyeJXEW9sp9L-vl7bAVntBPlhj_d7TG_kdkL3Rj0jIc0YPGeOLd3Y1lBVloqRU8UdkxoSmJa9quUdmlFJdCqbUPjmIcUUpo1yoJ2S_ElJrrvWMfL_wA6YfblwWvm_fFvHPOOLPoyLglYsu_Z4hTQH6Yh18O9kUCzcWMCbXOJ-cLdowLYvWReuvMFw_JY876CM-u7vn5Nv7068nH8vzzx_OTo7PSyurKpW25Z2tFkrXIJWWjGKtGomy4g1IsAwp1LTT0FAtoBGdXYCskVHorARkwOfk9a1vTnU5YUxmyBGw72FEP0XDJBVCcpa3nZNXD9CVn8KY020oJVWlmfhLLaFH48bOpwB2Y2qOuapFxTKaqZc7KLt2l-Zf6HAHlE-Lg7P5FzuX37dc32wJMpPwV1rCFKM5u_jyH-ynbfbF3eZTM2Br1sENEK7NfQsywG8BG3yMATtjXYLksmcA1xtGzaZrJnfNbLpmNl3LqvKB6t54N38DikjRJw |
| CODEN | CJMIAZ |
| CitedBy_id | crossref_primary_10_1007_s10482_018_1088_7 crossref_primary_10_3389_fmicb_2022_1039687 crossref_primary_10_1016_j_bmc_2021_115995 crossref_primary_10_1021_acs_jmedchem_5b01098 crossref_primary_10_1016_j_bbagen_2018_10_011 crossref_primary_10_1080_20477724_2021_2014235 crossref_primary_10_1038_s41587_019_0241_9 crossref_primary_10_1080_13880209_2018_1462834 crossref_primary_10_4103_2221_1691_360564 crossref_primary_10_3390_ph17070957 crossref_primary_10_52711_0974_360X_2022_00762 crossref_primary_10_1021_acs_jmedchem_8b00790 crossref_primary_10_3390_bacteria4010016 crossref_primary_10_1007_s11157_017_9438_x crossref_primary_10_3389_fmicb_2019_02153 crossref_primary_10_1128_spectrum_02672_22 crossref_primary_10_1186_s13568_021_01251_3 crossref_primary_10_1016_j_bioorg_2020_103921 crossref_primary_10_1021_jacs_5b01794 crossref_primary_10_1016_j_micpath_2023_106108 crossref_primary_10_2478_ast_2020_0006 crossref_primary_10_3390_antibiotics8020052 crossref_primary_10_3390_antibiotics8030154 crossref_primary_10_7717_peerj_12193 crossref_primary_10_1039_D3RA06831E crossref_primary_10_1111_cbdd_13685 crossref_primary_10_1016_j_chembiol_2017_12_011 crossref_primary_10_1080_10826068_2024_2364234 crossref_primary_10_2478_s11756_018_0090_x crossref_primary_10_1016_j_disamonth_2020_100971 crossref_primary_10_1002_aoc_5189 crossref_primary_10_3390_antibiotics9060297 crossref_primary_10_3390_agriculture6030037 crossref_primary_10_1038_ja_2017_101 crossref_primary_10_1007_s10725_021_00712_w crossref_primary_10_1016_j_bcab_2017_01_011 crossref_primary_10_22207_JPAM_13_2_14 crossref_primary_10_3389_fpubh_2020_535668 crossref_primary_10_1039_C5AN00171D crossref_primary_10_1021_acs_oprd_7b00033 crossref_primary_10_1016_j_bioactmat_2021_06_023 crossref_primary_10_1039_C7NP00006E crossref_primary_10_1021_acs_jafc_5b00778 crossref_primary_10_3390_antibiotics12081253 crossref_primary_10_1038_nature14193 crossref_primary_10_1021_acschembio_6b00176 crossref_primary_10_1016_j_jwpe_2020_101811 crossref_primary_10_1016_j_colsurfb_2016_05_046 crossref_primary_10_1016_j_trac_2022_116900 crossref_primary_10_1016_j_mib_2019_10_012 crossref_primary_10_1038_s41429_024_00750_2 crossref_primary_10_51847_r2fEu5aJXs crossref_primary_10_3390_jmse7060176 crossref_primary_10_1073_pnas_1614680114 crossref_primary_10_1016_j_sna_2022_113912 crossref_primary_10_1128_AAC_00991_15 crossref_primary_10_1155_2017_4962707 crossref_primary_10_3390_ijms241512446 crossref_primary_10_1002_mbo3_1035 crossref_primary_10_3389_fmicb_2018_00129 crossref_primary_10_1128_AAC_01943_17 crossref_primary_10_1016_j_msec_2019_109830 crossref_primary_10_3390_antibiotics10060621 crossref_primary_10_1002_aoc_5246 crossref_primary_10_3389_fmicb_2020_00976 crossref_primary_10_1016_j_synbio_2018_09_001 crossref_primary_10_3390_md15070205 crossref_primary_10_1016_j_bmc_2016_09_014 crossref_primary_10_3390_ijms222413363 crossref_primary_10_1016_j_copbio_2015_02_004 crossref_primary_10_3390_antibiotics12050929 crossref_primary_10_3390_molecules22071039 crossref_primary_10_1016_j_molcel_2018_03_001 crossref_primary_10_1016_j_procbio_2022_12_024 crossref_primary_10_1002_chem_202401955 crossref_primary_10_1007_s43393_022_00078_8 crossref_primary_10_30699_ijmm_13_2_132 crossref_primary_10_1016_j_sjbs_2017_01_004 crossref_primary_10_3390_molecules24101853 crossref_primary_10_3390_ijms22179596 crossref_primary_10_1002_ptr_5527 crossref_primary_10_2174_0929867327666200510235512 crossref_primary_10_4155_fmc_2020_0046 crossref_primary_10_3389_fmicb_2018_02551 crossref_primary_10_3390_ph16111615 crossref_primary_10_1021_np500775e crossref_primary_10_2174_2772434418666230316113927 crossref_primary_10_3390_ijms232415738 crossref_primary_10_1016_j_bsheal_2020_08_003 crossref_primary_10_1177_2472555218812657 crossref_primary_10_1002_aoc_5491 crossref_primary_10_1021_acsami_7b15147 crossref_primary_10_1128_AEM_01039_15 crossref_primary_10_1186_s11671_018_2718_8 crossref_primary_10_1016_j_tips_2016_05_001 crossref_primary_10_1021_acs_analchem_7b01025 crossref_primary_10_1002_pep2_24074 crossref_primary_10_1002_ppul_24382 crossref_primary_10_1111_jam_14682 crossref_primary_10_1111_tmi_13644 crossref_primary_10_15406_ppij_2017_05_00142 crossref_primary_10_2174_0118749445299557240510115134 crossref_primary_10_3390_molecules26185629 crossref_primary_10_52711_2321_5836_2024_00039 crossref_primary_10_1039_C4NP00134F crossref_primary_10_1016_j_bioorg_2021_104658 crossref_primary_10_1021_acs_bioconjchem_6b00676 crossref_primary_10_1016_j_yexcr_2018_05_006 crossref_primary_10_1007_s10570_021_04107_y crossref_primary_10_1016_j_jpba_2019_112833 crossref_primary_10_2478_rrlm_2018_0020 crossref_primary_10_1016_j_ejmech_2018_06_023 crossref_primary_10_1021_acs_biomac_5b00758 crossref_primary_10_1007_s41745_023_00385_6 crossref_primary_10_1016_j_ijbiomac_2018_05_217 crossref_primary_10_2174_1871529X19666190415110724 crossref_primary_10_1021_acsinfecdis_1c00281 crossref_primary_10_1007_s40506_023_00267_6 crossref_primary_10_3389_fmolb_2020_00023 crossref_primary_10_31594_commagene_399819 crossref_primary_10_13070_mm_en_8_2671 crossref_primary_10_4103_picr_PICR_162_18 crossref_primary_10_1186_s40168_019_0781_8 crossref_primary_10_1016_j_tet_2015_09_069 crossref_primary_10_1038_s41586_020_1990_9 crossref_primary_10_1016_j_molstruc_2017_12_002 crossref_primary_10_1134_S1995078018020180 crossref_primary_10_3390_molecules26237216 crossref_primary_10_1038_s42004_024_01153_y crossref_primary_10_1021_acs_jnatprod_2c00881 crossref_primary_10_2144_fsoa_2019_0034 crossref_primary_10_1021_acsinfecdis_7b00149 crossref_primary_10_1038_s41598_019_38789_z crossref_primary_10_3390_antibiotics7040085 crossref_primary_10_1016_j_bcp_2017_03_008 crossref_primary_10_1038_s41598_017_09672_6 crossref_primary_10_1089_mdr_2020_0178 crossref_primary_10_1002_ptr_6664 crossref_primary_10_1039_C5MD00394F crossref_primary_10_1007_s12539_017_0261_4 crossref_primary_10_26724_2079_8334_2018_2_64_123_126 crossref_primary_10_3389_fphar_2022_849006 crossref_primary_10_1021_acs_orglett_5b00596 crossref_primary_10_1080_21691401_2018_1448988 crossref_primary_10_1088_1742_6596_1795_1_012022 crossref_primary_10_3762_bjoc_12_95 crossref_primary_10_1016_j_jiph_2020_10_018 crossref_primary_10_1038_ja_2016_138 crossref_primary_10_3389_fcimb_2021_684515 crossref_primary_10_3390_jox15010019 crossref_primary_10_3389_fmicb_2019_01404 crossref_primary_10_1126_science_abm6509 crossref_primary_10_2196_28307 crossref_primary_10_1134_S0022476618070053 crossref_primary_10_1016_j_bsheal_2022_03_010 crossref_primary_10_1021_acs_jnatprod_4c01289 crossref_primary_10_48198_NJPAS_20_A16 crossref_primary_10_1128_ecosalplus_ESP_0027_2020 crossref_primary_10_3389_fmicb_2022_908336 crossref_primary_10_1016_j_ijid_2016_09_005 crossref_primary_10_1126_science_abn8327 crossref_primary_10_2216_14_092_1 crossref_primary_10_1079_cabireviews_2023_0029 |
| Cites_doi | 10.1038/nrd3975 10.1128/CMR.00037-09 10.1038/ja.2005.1 10.1042/BJ20130101 10.1093/cid/cit578 10.1128/AAC.01277-13 10.1128/AAC.50.2.519-526.2006 10.1021/np200254t 10.1128/AEM.02800-07 10.1021/sb300092n 10.1002/anie.200353160 10.1038/nrd1609 10.1126/science.1180823 10.1017/S1462399410001766 10.1016/S0169-409X(96)00423-1 10.1021/cb300269g 10.1038/nmeth.1239 10.1016/S1473-3099(13)70318-9 10.1038/msb4100050 10.1038/nchembio.1361 10.1016/j.chom.2008.08.001 10.1021/ja4115924 10.1016/S1074-5521(03)00046-2 10.1128/JB.00859-10 10.1016/j.chembiol.2012.06.013 10.1126/science.1120800 10.1073/pnas.1203689109 10.1073/pnas.1206376109 10.1002/cbic.201100500 10.1038/nature04784 10.1128/AEM.07227-11 10.1093/nar/gkt449 10.1128/AAC.00482-11 10.1039/c2np20104f 10.1016/j.tibs.2013.11.002 10.1139/cjm-2013-0089 10.1038/nchembio.559 10.1016/0002-9343(83)90088-8 10.1039/c2ob25835h 10.1021/ja909118a 10.1038/417141a 10.1038/ng.2478 10.1073/pnas.96.5.1846 10.1016/j.copbio.2011.03.010 10.1126/science.1116739 10.1111/j.1749-6632.1966.tb41199.x 10.1039/c3np20094a 10.1021/np400413s 10.1021/sb300101g 10.1128/mBio.00459-13 10.1016/j.bbapap.2008.11.005 10.1038/nbt.2685 10.1086/647938 10.1007/s10295-013-1383-2 10.1371/journal.pone.0081969 10.1039/c3np70063a 10.1038/ja.2013.25 10.1002/chem.201001279 10.1021/cb300413m 10.1038/ja.2010.13 10.1038/nrd2201 10.1016/j.coph.2012.06.010 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2014 NRC Research Press Copyright Canadian Science Publishing NRC Research Press Mar 2014 |
| Copyright_xml | – notice: COPYRIGHT 2014 NRC Research Press – notice: Copyright Canadian Science Publishing NRC Research Press Mar 2014 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM ISN ISR 7QL 7SN 7U9 8FD C1K FR3 H94 K9. M7N NAPCQ P64 RC3 7X8 |
| DOI | 10.1139/cjm-2014-0063 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Canada Gale In Context: Science Bacteriology Abstracts (Microbiology B) Ecology Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Algology Mycology and Protozoology Abstracts (Microbiology C) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nursing & Allied Health Premium Genetics Abstracts Virology and AIDS Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Ecology Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Nursing & Allied Health Premium MEDLINE - Academic MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1480-3275 |
| EndPage | 154 |
| ExternalDocumentID | 3244079651 A367421065 24588388 10_1139_cjm_2014_0063 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Feature |
| GeographicLocations | United States Canada |
| GeographicLocations_xml | – name: United States – name: Canada |
| GrantInformation_xml | – fundername: Canadian Institutes of Health Research |
| GroupedDBID | --- -~X .55 00T 0R~ 29B 2QL 2XV 36B 3O- 4.4 4IJ 53G 5GY 5RE 5RP 6J9 7RV 7X2 7X7 88E 88I 8AF 8AO 8CJ 8FE 8FH 8FI 8FJ 8FQ 8G5 A8Z AAHBH AAIKC AAMNW AAYXX ABCQX ABDBF ABEFU ABJNI ABUWG ACGFO ACGFS ACGOD ACNCT ACPRK ACUHS ADBBV ADXHL AEGXH AENEX AEUYN AFFNX AFKRA AFRAH AHMBA AIAGR ALIPV ALMA_UNASSIGNED_HOLDINGS APEBS ATCPS AZQEC BBNVY BCR BENPR BHPHI BKEYQ BKSAR BLC BPHCQ BVXVI CAG CCPQU CITATION COF CS3 D1J D8U DU5 DWQXO EAD EAP EAS EBC EBD EBS ECC EDH EJD EMB EMK EMOBN EPL EST ESTFP ESX EX3 F5P FYUFA GNUQQ GUQSH HCIFZ HMCUK HZ~ H~9 IAG IAO ICQ IEA IEP IGS IHR INH INR IPNFZ ISN ISR ITC L7B LK8 M0K M1P M2O M2P M2Q M3C M3G M7P ML0 MM. MV1 MVM NAPCQ NEJ NMEPN NRXXU NYCZX O9- OHT ONR OVD P2P PCBAR PHGZM PHGZT PQQKQ PRG PROAC PSQYO PV9 QF4 QM4 QN7 QO4 QRP RIG RRCRK RRP RZL S10 SV3 TEORI TN5 TUS U5U UKHRP VQG WH7 WOW X7M YZZ ZCG ZGI ZY4 ABTAH CGR CUY CVF ECM EIF NPM 7QL 7SN 7U9 8FD C1K FR3 H94 K9. M7N P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c522t-cd3fc29687a568510e76b5e523ba5ac1e0a70f8ab084ab4fc9a57e10afc5ae1a3 |
| ISSN | 0008-4166 1480-3275 |
| IngestDate | Fri Jul 11 09:29:38 EDT 2025 Sat Aug 16 05:21:33 EDT 2025 Wed Mar 19 00:40:51 EDT 2025 Tue Jun 10 15:32:42 EDT 2025 Sat Mar 08 18:37:19 EST 2025 Wed Mar 05 04:42:44 EST 2025 Wed Mar 05 05:19:11 EST 2025 Thu Apr 03 07:06:15 EDT 2025 Tue Jul 01 04:27:59 EDT 2025 Thu Apr 24 22:49:47 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c522t-cd3fc29687a568510e76b5e523ba5ac1e0a70f8ab084ab4fc9a57e10afc5ae1a3 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://cdnsciencepub.com/doi/pdf/10.1139/cjm-2014-0063 |
| PMID | 24588388 |
| PQID | 1506562814 |
| PQPubID | 6731 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1504453188 proquest_journals_1506562814 gale_infotracmisc_A367421065 gale_infotraccpiq_367421065 gale_infotracacademiconefile_A367421065 gale_incontextgauss_ISR_A367421065 gale_incontextgauss_ISN_A367421065 pubmed_primary_24588388 crossref_citationtrail_10_1139_cjm_2014_0063 crossref_primary_10_1139_cjm_2014_0063 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-03-01 |
| PublicationDateYYYYMMDD | 2014-03-01 |
| PublicationDate_xml | – month: 03 year: 2014 text: 2014-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Canada |
| PublicationPlace_xml | – name: Canada – name: Ottawa |
| PublicationTitle | Canadian journal of microbiology |
| PublicationTitleAlternate | Can J Microbiol |
| PublicationYear | 2014 |
| Publisher | NRC Research Press Canadian Science Publishing NRC Research Press |
| Publisher_xml | – name: NRC Research Press – name: Canadian Science Publishing NRC Research Press |
| References | refg47/ref47 refg40/ref40 refg65/ref65 refg18/ref18 refg22/ref22 refg36/ref36 refg51/ref51 refg11/ref11 refg25/ref25 refg6/ref6 refg15/ref15 refg29/ref29 refg43/ref43 refg26/ref26 refg14/ref14 refg5/ref5 refg54/ref54 refg57/ref57 refg37/ref37 refg19/ref19 refg21/ref21 refg7/ref7 refg4/ref4 refg46/ref46 refg48/ref48 refg10/ref10 refg32/ref32 refg35/ref35 refg59/ref59 refg61/ref61 refg53/ref53 refg42/ref42 refg24/ref24 refg16/ref16 refg50/ref50 refg64/ref64 refg13/ref13 refg27/ref27 refg56/ref56 refg20/ref20 refg38/ref38 refg45/ref45 refg49/ref49 refg31/ref31 refg9/ref9 refg34/ref34 refg52/ref52 refg8/ref8 refg60/ref60 refg63/ref63 refg23/ref23 refg17/ref17 refg30/ref30 refg12/ref12 refg28/ref28 refg41/ref41 refg55/ref55 refg39/ref39 refg3/ref3 refg62/ref62 refg44/ref44 refg58/ref58 refg33/ref33 |
| References_xml | – ident: refg32/ref32 doi: 10.1038/nrd3975 – ident: refg18/ref18 doi: 10.1128/CMR.00037-09 – ident: refg5/ref5 doi: 10.1038/ja.2005.1 – ident: refg36/ref36 doi: 10.1042/BJ20130101 – ident: refg11/ref11 doi: 10.1093/cid/cit578 – ident: refg47/ref47 doi: 10.1128/AAC.01277-13 – ident: refg62/ref62 doi: 10.1128/AAC.50.2.519-526.2006 – ident: refg40/ref40 doi: 10.1021/np200254t – ident: refg55/ref55 doi: 10.1128/AEM.02800-07 – ident: refg50/ref50 doi: 10.1021/sb300092n – ident: refg6/ref6 doi: 10.1002/anie.200353160 – ident: refg30/ref30 doi: 10.1038/nrd1609 – ident: refg13/ref13 doi: 10.1126/science.1180823 – ident: refg28/ref28 doi: 10.1017/S1462399410001766 – ident: refg33/ref33 doi: 10.1016/S0169-409X(96)00423-1 – ident: refg49/ref49 doi: 10.1021/cb300269g – ident: refg10/ref10 doi: 10.1038/nmeth.1239 – ident: refg31/ref31 doi: 10.1016/S1473-3099(13)70318-9 – ident: refg3/ref3 doi: 10.1038/msb4100050 – ident: refg65/ref65 doi: 10.1038/nchembio.1361 – ident: refg22/ref22 doi: 10.1016/j.chom.2008.08.001 – ident: refg53/ref53 doi: 10.1021/ja4115924 – ident: refg29/ref29 doi: 10.1016/S1074-5521(03)00046-2 – ident: refg48/ref48 doi: 10.1128/JB.00859-10 – ident: refg15/ref15 doi: 10.1016/j.chembiol.2012.06.013 – ident: refg16/ref16 doi: 10.1126/science.1120800 – ident: refg57/ref57 doi: 10.1073/pnas.1203689109 – ident: refg27/ref27 doi: 10.1073/pnas.1206376109 – ident: refg58/ref58 doi: 10.1002/cbic.201100500 – ident: refg56/ref56 doi: 10.1038/nature04784 – ident: refg39/ref39 doi: 10.1128/AEM.07227-11 – ident: refg7/ref7 doi: 10.1093/nar/gkt449 – ident: refg45/ref45 doi: 10.1128/AAC.00482-11 – ident: refg8/ref8 doi: 10.1039/c2np20104f – ident: refg59/ref59 doi: 10.1016/j.tibs.2013.11.002 – ident: refg9/ref9 doi: 10.1139/cjm-2013-0089 – ident: refg20/ref20 doi: 10.1038/nchembio.559 – ident: refg37/ref37 doi: 10.1016/0002-9343(83)90088-8 – ident: refg60/ref60 doi: 10.1039/c2ob25835h – ident: refg54/ref54 doi: 10.1021/ja909118a – ident: refg4/ref4 doi: 10.1038/417141a – ident: refg24/ref24 doi: 10.1038/ng.2478 – ident: refg34/ref34 doi: 10.1073/pnas.96.5.1846 – ident: refg41/ref41 doi: 10.1016/j.copbio.2011.03.010 – ident: refg26/ref26 doi: 10.1126/science.1116739 – ident: refg43/ref43 doi: 10.1111/j.1749-6632.1966.tb41199.x – ident: refg44/ref44 doi: 10.1039/c3np20094a – ident: refg61/ref61 doi: 10.1021/np400413s – ident: refg63/ref63 doi: 10.1021/sb300101g – ident: refg52/ref52 doi: 10.1128/mBio.00459-13 – ident: refg17/ref17 doi: 10.1016/j.bbapap.2008.11.005 – ident: refg51/ref51 doi: 10.1038/nbt.2685 – ident: refg19/ref19 doi: 10.1086/647938 – ident: refg12/ref12 doi: 10.1007/s10295-013-1383-2 – ident: refg64/ref64 doi: 10.1371/journal.pone.0081969 – ident: refg23/ref23 – ident: refg38/ref38 doi: 10.1039/c3np70063a – ident: refg14/ref14 doi: 10.1038/ja.2013.25 – ident: refg25/ref25 doi: 10.1002/chem.201001279 – ident: refg21/ref21 doi: 10.1021/cb300413m – ident: refg35/ref35 doi: 10.1038/ja.2010.13 – ident: refg42/ref42 doi: 10.1038/nrd2201 – ident: refg46/ref46 doi: 10.1016/j.coph.2012.06.010 |
| SSID | ssj0010346 |
| Score | 2.494363 |
| Snippet | Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there... Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi- antibiotic-resistant pathogens, there... |
| SourceID | proquest gale pubmed crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 147 |
| SubjectTerms | Actinomycetes Analytical chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Bacteria - drug effects Bacteria - genetics Bacteria - growth & development Biofilms - drug effects Bioinformatics Biological Evolution Biological Products - chemistry Biological Products - pharmacology Biological Products - therapeutic use Dosage and administration Drug Discovery - trends Drug Industry - trends Drug resistance Drug Resistance, Multiple, Bacterial - drug effects Drug Resistance, Multiple, Bacterial - genetics Drug Therapy, Combination Health aspects Humans Legislation, Drug Microbiological research Natural products Pharmaceutical industry Pharmaceutical research Pharmacokinetics R&D Research & development United States Virulence Factors - antagonists & inhibitors |
| Title | Something old, something new: revisiting natural products in antibiotic drug discovery |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24588388 https://www.proquest.com/docview/1506562814 https://www.proquest.com/docview/1504453188 |
| Volume | 60 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZgV0hcEG-2XZBBCC4N5GEnDrdtoRQkeugD9WbZTlIFtUnZxwF-PTOxk2xaioBLtHImj53PnswkM98Q8jKJWRGqNPF0xAqP5WHmpVqkXuoXBTOFAR8fC4W_7Md7x-zzCT_pW_o11SVL_cb8_G1dyf-gCmOAK1bJ_gOy3UlhAH4DvrAFhGH7Vxgf1tgAuslbtu93F90AeMsY7M-b4vEmtbmh8MS6K8vx2uTBglpLXdZI2prNV6f4ucZgTufgW29HYLDGMnFe9gROVwP9j1jVnLlkYvdKIWB9TpXNuDjY6fL-Bpkg1oIKD5y4eN2C2o4AbqZEa-YwsGyaV810hCyn5tu5Zy_vOyM3ZL6eRTEE7hCz8ptkHEIYEI7IeLb9fnt33PeosKVY7V21LKpR-nZw9oHXcfnZeymiaDyLo7vkjgsJ6Mzie4_cyKv75JZtEvrjAfnaoUwB5S3aYUwB43e0R5g6hGmLMC0r2iNMEWHaIfyQHO9-ONrZ81w3DM-Aj7z0TBbB0kljkSgeg5_s50msec7DSCuuTJD7KvELobQvmNKsMKniSR74qjBc5YGKHpFRVVf5E0JZEILZZXFWCMF4KkTmq1ibgGu4htB8QrZabUnjqOKxY8mZbELGKJWgXInKlajcCXnViV9YjpTrBF-g6iXyjlSY2HSqVouF_HS4L3usrxU6GAi9dkJFDXdmlCsmgf-HfGYDyc2BpLkov8u1vdPBXrCtZnDwtJ0k0q2xhUROTogaRMAm5Hm3G4_EfMUqr1eNDGPweBNiQh7bydWpJsTi8EiIjT9fe5Pc7tfmlIyW81X-FBzgpX7mVsEvJQGwhw |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Something+old%2C+something+new%3A+revisiting+natural+products+in+antibiotic+drug+discovery&rft.jtitle=Canadian+journal+of+microbiology&rft.au=Wright%2C+Gerard+D&rft.date=2014-03-01&rft.pub=NRC+Research+Press&rft.issn=0008-4166&rft.volume=60&rft.issue=3&rft.spage=147&rft_id=info:doi/10.1139%2Fcjm-2014-0063&rft.externalDocID=A367421065 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0008-4166&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0008-4166&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0008-4166&client=summon |