Influence of Sex and Corticotropin-Releasing Factor Pathways as Determinants in Serotonin Sensitivity

• Published in: Endocrinology (Philadelphia) Vol. 150; no. 8; pp. 3709 - 3716
• Main Authors: McEuen, Jonathan G, Semsar, Katharine A, Lim, Maria A, Bale, Tracy L
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Endocrine Society 01.08.2009; The Endocrine Society
• Subjects: Animals; Autoradiography; Biological and medical sciences; Citalopram - pharmacology; Corticotropin-Releasing Hormone - metabolism; Corticotropin-Releasing Hormone - physiology; Female; Fundamental and applied biological sciences. Psychology; Genotype; Hindlimb Suspension; Male; Maze Learning - drug effects; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Receptors, Corticotropin-Releasing Hormone - genetics; Receptors, Corticotropin-Releasing Hormone - physiology; Serotonin - metabolism; Serotonin - physiology; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin Uptake Inhibitors - pharmacology; Sex Factors; Vertebrates: endocrinology; Hypothalamic hormone; Neurotransmitter; Sensitivity; Serotonin; Hormone releasing factor; Corticotropin releasing factor

Stress sensitivity and sex are predictive factors in affective disorder susceptibility. Serotonin (5-HT) pathway recruitment by corticotropin-releasing factor (CRF) during stress is necessary in adaptive coping behaviors, but sex differences in such responses have not been investigated. Using select...