Bivartect: accurate and memory-saving breakpoint detection by direct read comparison

• Published in: Bioinformatics Vol. 36; no. 9; pp. 2725 - 2730
• Main Authors: Shimmura, Keisuke, Kato, Yuki, Kawahara, Yukio
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2020
• Subjects: Original Papers

Abstract Motivation Genetic variant calling with high-throughput sequencing data has been recognized as a useful tool for better understanding of disease mechanism and detection of potential off-target sites in genome editing. Since most of the variant calling algorithms rely on initial mapping onto...